BetaThis search tool is in development. Find out more.
Find thousands of books, manuscripts, visual materials and unpublished archives from our collections, many of them with free online access.
Digital Images

Clonal differentiation in the mouse embryo

Dr M. Zernicka-Goetz, Gurdon Institute

Available online

view Clonal differentiation in the mouse embryo

License

CC0 1.0 Universal
You can use this work for any purpose without restriction under copyright law.
Creative Commons Zero (CC0) terms and conditions https://creativecommons.org/publicdomain/zero/1.0
Credit: Clonal differentiation in the mouse embryo. Credit: A. Jedrusik & M. Zernicka-Goetz, Gurdon Institute. CC0 1.0 Universal

Selected images from this work


About this work

Description

A 3D reconstruction of an early mouse blastocyst. The blastocyst is formed three- four days post fertilization in the mouse and it is at this stage that the cells start to differentiate. Two types of cells form, those that will be part of the inner cell mass and ultimately form the fetus and the others become part of the trophectoderm and will act as the supporting cells forming structures like the placenta. In this embryo Cdx2 was over-expressed in half the embryo at the two-cell-stage. The Cdx2 gene is essential for correct organisation in the early embryo in mice and required for placenta formation. Without this gene the embryo would fail to form. The cells that resulted from the half of the embryo that over expressed this gene contributed disproportionally to the trophectoderm (shown in pink). The cells from the non-injected half of the embryo are shown in yellow.


Permanent link


We’re improving the information on this page. Find out more.