Functional and molecular glycobiology / S.A. Brooks, M.V. Dwek, U. Schumacher.

Functional & molecular glycobiology

Oxford : BIOS Scientific ; New York : Distributed in the U.S. by Springer-Verlag, 2002.

xvi, 354 pages : illustrations ; 25 cm.

Copy 1 Donor: Wellcome Trust Sanger Institute.

An introduction to carbohydrate chemistry -- What are carbohydrates? -- Monosaccharides are aldoses and ketoses -- A carbon atom may be asymmetric - the concept of chirality -- Monosaccharide 'family trees' -- D-Forms and l-forms of carbohydrates -- Numbering the carbon atoms in a monosaccharide molecule -- (+) and (-) forms of carbohydrates -- The concept of epimerization -- Monosaccharides form ring structures -- How the rings are formed - the formation of hemiacetals and hemiketals -- Monosaccharide [alpha]- and [beta]-anomers -- Equilibrium between different structures -- Examples of some biologically important monosaccharides -- Examples of some important monosaccharide derivatives -- The linking together of monosaccharides to form chains -- [alpha]- and [beta]-glycosidic bonds -- Different linkages -- Conventions for describing oligosaccharides -- Reducing sugars -- Examples of biologically important disaccharides -- Ways of illustrating oligosaccharide chains -- The complex carbohydrate structure database (CCSD) -- Enzymes of glycosylation - the glycosyltransferases -- Enzymes of glycosylation - glycosidases and glycosyltransferases -- Nomenclature of glycosyltransferases -- Initiation of glycosylation by glycosyltransferases -- Building oligosaccharides - transglycosylation reactions -- Sugar donors -- The 'one enzyme-one linkage' rule - and exceptions to it -- Cation and pH requirements of glycosyltransferases -- Localization of glycosyltransferases along the secretory pathway -- Substrate recognition by glycosyltransferases.

Includes bibliographical references and index.