Beyond thalidomide : birth defects explained / Janet McCredie.

London ; Ashland, OH : Royal Society of Medicine Press, [2007], ©2007.

xii, 418 pages : illustrations (some color) ; 26 cm

Includes bibliographical references and index.

The thalidomide epidemic -- Pharmacology of thalidomide: interaction with the human embryo -- Animal studies -- Thalidomide polyneuropathy -- Clinical radiology -- Terminology, classification and the rejection of authority -- The pattern of the disease: first radiological analysis (Sydney) -- Verification of the disease pattern: second radiological analysis (London) -- Congenital reductions of the radius -- Congenital dislocation -- Congenital synostosis -- The hypothesis of neural crest injury -- The neural crest -- Neurotrophism -- Nerve in limb bud -- Regeneration and embryogenesis -- Neural crest ablation and limb morphogenesis -- Thalidomide deformities and their nerve supply: first morphometirc study in rabbits -- Thalidomide deformities and their nerve supply: second morphometric study in rabbits -- The sensory nerve supply of bone -- The sclerotomes -- Sclerotome aplasia/subtraction -- Sclerotome aplasia/subtraction in 203 cases -- Radial/tibial dysmelia: limb reductions typical of thalidomide -- Associated internal malformations and their embryology -- Neurotomes and multiple malformation syndromes -- Hands and feet in thalidomide embryopathy: histology and sclerotomes in the digits -- Other disorders of similar sclerotomes -- Segmental and truncal neuorpathies in sclerotomes not affected by thalidomide -- Review of actions of thalidomide -- Conclusion: beyond thalidomide.