Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry.

  • Terry, B. T. (Benjamin Taylor), 1876-
Date:
1911
Catalogue details

Licence: In copyright

Credit: Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

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    eleventh day (control on the second). The unportance of the above observation will become evident if the incubation periods in the preceding and following- tables are carefully studied, for we shall find that immunity nearly always delays infection, while, under similar conditions, unexcreted medicament does so only rarely. That the immunity to surra of India develops very early after treatment with Cl is shown by the following experiment. 1. sr.-.' 1 Ole-i + o '?SI[M]f-'.^ H-21 0 D. 2. sr.'-^.' ICC-'- 2 'OT'''5,,3s27 oOl.-» ° oOll-J 17-S7 0 L. 3. sr.-. 4 8-15 oOl.-« 0 H-J7 O L. 4. Sli-'ts-j 9 '•OT-'' > *■ l'-^ oOl4-« 0 + 5. sri-«,2-« 13 HOT'«3 16-2' SS-M t D. 6. SL-4.VS 16 OT-2'* -'^ oOJL»-« o o Of the tests made one, two, and four days after treatment (mice I, 2, and 3), the first alone visibly infected. The failure of those made on the second and fourth days is attributed to the presence of immunity, for prophylactic experiments have shown that a rich intraperitoneal inoculation of surra of India may infect when given as early as twenty-four hours after Cl. From the richness of the injections employed on tlie second and fourth days, it seems almost certain that the prevention of infection in these two mice was not due to unexcreted medicament, but to the development of immunity. Furthermore, the early appearance of immunity is apparently shown by the mouse which became infected (No. i), as well as by those that remained negative, for the first animal was positive for one day only, then recovered and was found to be immune when retested on the sixteenth day. It is very probable that in both the first and the second animals an immunity zvas present by the third day after treatment. Following a single injection of Cl, an immunity to surra of India was present in three mice tested as late as the twenty-eighth day (twenty-seven days after treatment). In the case of two (mice 4 and 5), the immunity was shown by the delay in infection. These animals became positive after incubation periods of six and seven days respectively, while the control was infected on the second day. In the sixth mouse the immunity was stronger, for