Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry.

  • Terry, B. T. (Benjamin Taylor), 1876-
Date:
1911
Catalogue details

Licence: In copyright

Credit: Chemo-therapeutic trypanosome studies with special reference to the immunity following cure / by B.T. Terry. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

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    Relapses were rarely seen after treatment with the above medica- ments and then only after injections of dichlorbenzidine. The favorable results are attributed to the great efficiency of the arsenic preparations and the mixtures, to the fact that the dyes were em- ployed by themselves only against the trypanosomes known to be susceptible to them (i. e., dichlorbenzidine in the treatment of the surras, and trypanred in the treatment of caderas), and in part to the prevention of leakage after treatment. Criterion of Cure.—Mice which remained negative for fifty con- secutive days following a curative treatment with one of the above medicaments are regarded as cured. Nevertheless, to be perfectly sure, the blood examinations were continued long after the fiftieth day, and the majority of the animals were kept under observation for six months. While keeping the mice for one hundred and eighty days may be useful in determining the toxic effects of the medica- ments employed, this is not necessary to make certain of the cure. Relapses- usvially take place in the first three weeks, and in my ex- periments the longest observed interval between the disappearance of the parasites and their reappearance has been thirty days. The records in some instances are incomplete, for on leaving the Pasteur Institute in August, 1907, observation of a number of animals had to be discontinued. Concerning their subsequent his- tory I can make no statement, but in my outlines and descriptions the number of days these animals were followed is indicated. The Outlines.—The influences capable of affecting the immunity following cure are so numerous that an adequate analysis of the results necessitated the finding of some form by which these factors could be briefly yet clearly expressed. After many trials, outlines were devised which proved so helpful that it seemed desirable to employ them in reporting my results. It was found, however, that a number of changes had to be made in order to adapt them for printing. In making these alterations. Dr. W. H. Manwaring rendered invaluable assistance. Explanation of Outlines.—The outlines are read from left to right, each line representing a different mouse, no other animal being employed in the immunity tests. In order to avoid the print- ing of common fractions, these, in each instance, have been con-