On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond.

  • Marchiafava, Ettore, 1847-1935.
Date:
1888
Catalogue details

Licence: Public Domain Mark

Credit: On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond. Source: Wellcome Collection.

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    2nd Case. Comatose Pernicious Fever.—P. E., retat 40, entered thè hospital September 29th, in thè afternoon, in an accès of comatose perniciosa. There was no previous history, only that he carne from thè Campagna. He died next morning. Microscopie examination showed scattered pigmented white cells ; red globules with pigmented corpuscles ; numerous liyaline bodies of different shapes, spherical, ovai, fusiform, semi-lunar, containing granules and pigment masses. Some of these liyaline bodies had at their periphery a zone of protoplasm coloured with haamoglobin ; a certain semi-lunar form was thè result of thè conversion of one-half a red globulo into a pigmented liyaline mass, whilst thè other remained decolorized, and onlv its delicate outline was visible. The examination made sliortly before death showed a great nurnber of pigmented white globules. The stained preparations presented numerous red globules containing round corpuscles either in centre, at periphery, uni- formly stained, with a vacuolo in thè centre, or blue rings of various size and form. Autopsy (7 hours after death).—(Edema of thè membranes ; punctiform hamiorrhages of white cerebral substance ; grey substance dark red ; bilateral pulmonary oedema ; liydrotkorax ; hydropericardium ; heart normal ; myocardium brownish red colour ; spleen triply enlarged, of triangular form, very soft, ol a chocolate colour ; liver dark grey colour ; lobules indistinct ; kidneys dark grey colour, exsanguined. The result of thè microscopie examination was thè same as during life. As to thè examination of organs liardened and stained, it deserves to he recorded that thè capillaries of thè brain were distended with red globules, containing thè corpuseles mentioned, deeply stained, and without trace of pigment. The pigmented white globules were rarely met with in these capil- laries. 3rd Case. Comatose Pernicious Fever.—M. L., a carter out- side thè Porta Maggiore, entered thè hospital at 10 a.m., Oct. G, already profoundly comatose and with high fever ; said to bave sufiered some days from fever, and found that morning in this condition in a stable. After injection and internai administra- tion of quinine he rallied somewliat, reacted to cutaneous stimuli, but did not recover bis senses. After a little he sank into pro- found coma. Had very grave dyspnoea; pulso 140 ; temperature