Find thousands of books, manuscripts, visual materials and unpublished archives from our collections, many of them with free online access.

Misreplication of DNA in human fibroblast nucleus

  • Ezequiel Miron, University of Oxford
  • Digital Images
  • Online

Available online

view Misreplication of DNA in human fibroblast nucleus


Attribution 4.0 International (CC BY 4.0)
You can use this work for any purpose, including commercial uses, without restriction under copyright law. You should also provide attribution to the original work, source and licence.
Creative Commons Attribution (CC BY 4.0) terms and conditions
Credit: Misreplication of DNA in human fibroblast nucleus. Ezequiel Miron, University of Oxford. Attribution 4.0 International (CC BY 4.0)

Selected images from this work

About this work


Super-resolution optical micrograph of DNA stain in a human foetal lung fibroblast nucleus acquired with a 3D structured illumination microscope (3D SIM). A rare phenomenon has occurred in this image; the majority of the genome has been caught in misreplication. If a single chromosome becomes caught and pulled between the two new cells, it can lead to the presence of small chromatin threads/bridges joining adjacent nuclei. This leads to clearly demarcated chromatin fibres visible throughout the interior of the nucleus, and as the new cells move apart the tension distributed by the cable-like chromatin has deformed the entire nuclear envelope. The width of the image is 84 micrometers.

Permanent link