The rate of reproduction of various constituents of the blood of an immunised horse after a large bleeding / by R.A. O'Brien.

  • O'Brien, R.A.
Date:
1913
Catalogue details

Licence: In copyright

Credit: The rate of reproduction of various constituents of the blood of an immunised horse after a large bleeding / by R.A. O'Brien. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    The average error of any point on the curve is from 5 per cent, to 10 per cent. DiplitliBYici (infito.i'in was estimated in the usual way, the individual reading being correct to 5 per cent. and diphtheria antitoxin. Horse 2. Amounts of eonstituents expressed as percentages of amount present before bleeding. Eesults. The actual results obtained appear in Tables I. and IL, and some are expressed graphically in Figs. 1, 2, 3, and 4, for the construction of which the amount of each constituent at the commencement of bleeding is considered to be 100 per cent. The amount of blood removed (10 litres) was approximately one- fourth of the total blood volume, for although I have not yet succeeded in satisfactorily measuring the total blood volume, estimates obtained by bleeding out and by intravenous injection of known volumes of saline solution justify the assumption that the blood volume of horses of the same weight as those used is from 36 to 40 litres. The weight of Horse 1 was 680 kilos. It is stated by Athanasiu (1909 that the blood volume is the first of the blood constituents to regain the normal figure. If this be so, one woidd expect, after the removal of 10 litres, i.e., 25 per cent, of the total blood volume, that fluid would pour into the blood vessels until the volume was re-established, at which stage the blood constitu- ents should be about 75 per cent, of the initial figure, let in the case of Horse 1 the hmmoglobin and red cells drop on the third day