Improved method of and means for the vaccination of animals with virus / [Onésime Thomas].
- Thomas, Onésime.
- Date:
- 1901
Licence: Public Domain Mark
Credit: Improved method of and means for the vaccination of animals with virus / [Onésime Thomas]. Source: Wellcome Collection.
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![A.D. 1900 N° 16,999 Date of Application, 24th Sept., 1900—Accepted, 22nd June, 1901 COMPLETE SPECIFICATION Improved Method of and Means for the Vaccination of Animals with Virus. A communication from abroad by Onesime Thomas, of 19 Hue Cambon, Paris France, I, Reginald William James, of the Firm of Fell and James, of 1 Queen Victoria Street, in the City' of London, Chartered Patent Agent, do hereby declare the nature of this invention and in what manner the same is to be performed to be particularly described and ascertained in and by the following statement. 5 Vaccination by a virulent thread or one impregnated with virus, consists in inserting under the skin or in the muscles of an animal, a thread impregnated with a quick or slow acting virus, either natural or cultivated, for the purpose of creating an immunity and preservation from contagious diseases. It is inserted by means of a needle which with the thread takes the place of the 10 Pravar syringe and other instruments of innoculation. In order that immunity can be acquired without risk of death, it is absolutely necessary to give a dose of accurately measured quantity; too small a dose of virus will produce little or no effect, too great a dose will be followed by general infection and occasion death. Therefore in order to avoid these extremes, a 1 b thread impregnated with virus to an extent of mathematical precision is used. If is this method of preparation and dosing or proportioning that is the subject ol this application for a patent. It comprises several operations which we will now explain. The threads can be of cotton, wool, or any other material, the essential feature 20 is that they must be very w~ell spun, of uniform thickness, regularly twisted an! all foreign substances eliminated therefrom. They must be rendered antiseptic by a prolonged treatment in boiling water, or in a heated oven. Cotton threads will previously be rendered absorbent to moisture by ordinary processes. They are then wound on bobbins and placed in a very dry place or better still in a 2/5 drying oven or stove of moderate temperature. The impregnation is effected by drawing it through a virulent liquid of a suitable composition and strength. The bobbin filled with thread is placed on an axis and is unwound by a rotative movement. On leaving the bobbin the thread is immersed in the virulent liquid contained in a conical glass, reaches fo the bottom thereof and reascends after entering a discharge tube or device whence it is wound along a windlass to dry. The virulent liquid contained in the glass is thus traversed by the thread twice, from the top to the bottom and from the bottom to the top, a circumstance which permits of its treatment through the whole depth of liquid. The discharge tube or device is a part cylindrical and part conical glass tube. 30 3'j JO The cylindrical part is of smaller diameter adjacent to the bottom of the glass from which it is removed a distance of a few millimetres. The conical part is drawn down to a small orifice of exact and determined size. This operation can be effected in the following simple manner: — A steel wire of the diameter of the desired orifice is placed in the glass tube to form a matrix, and the glass tube is then drawn down as a pipe around the wire, the latter being withdrawn when the glass tube is cold. It is in traversing this orifice that the thread gets rid of the excess of absorbed [Price 8(/.]](https://iiif.wellcomecollection.org/image/b30735701_0001.jp2/full/800%2C/0/default.jpg)
