Mitogen-activated phosphokinase, mol. model

Molecular model of P38 mitogen-activated phosphokinase, ribbon diagram. N-domain or lobe (red) is mainly involved in protein-protein interactions and binding ATP. The C-domain or lobe (yellow) is the catalytic domain that interacts with the triphosphate groups of ATP. Two residues, Thr-180 and Tyr-182 (shown as ball-and-stick models), part of the phosphorylation lip (green), are phosphorylated upon activation and are responsible for shifts in the local environment unblocking the active site. P38 mitogen-activated protein kinase is a Ser/Thr kinase that is activated by environmental stress through various cytokines. It plays a role in transcriptional regulation and inflammatory responses.