Molecular model of P38 mitogen-activated
phosphokinase, ribbon diagram. N-domain or lobe
(red) is mainly involved in protein-protein
interactions and binding ATP. The C-domain or lobe
(yellow) is the catalytic domain that interacts
with the triphosphate groups of ATP. Two residues,
Thr-180 and Tyr-182 (shown as ball-and-stick
models), part of the phosphorylation lip (green),
are phosphorylated upon activation and are
responsible for shifts in the local environment
unblocking the active site.
P38 mitogen-activated protein kinase is a Ser/Thr
kinase that is activated by environmental stress
through various cytokines. It plays a role in
transcriptional regulation and inflammatory
responses.
