On the pathology and treatment of albuminuria / by W. Howship Dickinson.

Date:
1877
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology and treatment of albuminuria / by W. Howship Dickinson. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

    99/520 (page 63)
    the casts were numbers of unattached spherical epithelioid cells some of which contained granules of oil. After death the extreme general oedema was conspicuous as in life; and as further evidence of the general dropsy the pleural cavities contained much serum, the right most. To place the kidneys first: these were greatly enlarged, each weighing four and a quarter ounces. The capsules were thin, translucent, and non-adherent. The surfaces were perfectly smooth and ‘ mottled,’ large patches being ivory-white, while others were marked with stellate and capillary injections. In section the cortex was increased in thickness to from y^tlis to itks of an inch. Some parts corresponding to the white patches on the surface were nearly white, like the cut surface of a parsnip; others were injected to a reddish colour, under which a white substance was visible. The cones were injected, but were otherwise little changed. The whole organ dripped with blood. There was no lardaceous reaction. d he microscope showed the tubes, both in cortex and cones, to be irregularly and greatly distended with thick plugs, chiefly composed of fibrine. There was also a general profusion of interstitial nuclei, which Avere multiplied with much uniformity around the malpighian bodies and between the tubes. Around the malpighian bodies the fibroid growth generally amounted to a concentric envelope of nucleated growth of tangible thickness. Elsewhere the new ioimations were scarcely to be detected but by the number of intertubular nuclei. A section from one of these kidneys is represented at page 28. The heart weighed 6f ounces; it was of great proportionate size. Dr. Sibson kindly traced upon glass the outline it presented in relation to the chest. Both ventricles were thickened, the left most so; its walls were half an inch through, and the muscular columns within strikingly developed. The valves were healthy, nor was the lining of the great vascular cavities otherwise affected than by a couple of spots of atheroma upon the ascend- mg aoi ta. A more minute examination, however, of the arterial system showed changes not evident to the naked eye. The vessels of the pia mater not quite of the smallest size showed granular and fatty degenerations of the muscular coat. How far they were absolutely thickened was a matter of some doubt but that many of the muscular nuclei were coarsely fatty was Post- mortem ex- amination.