On the action of ergotoxine : with special reference to the existence of sympathetic vasodilators / by H.H. Dale.

  • Dale, Henry H. (Henry Hallett), 1875-1968.
Date:
[1913?]
Catalogue details

Licence: Public Domain Mark

Credit: On the action of ergotoxine : with special reference to the existence of sympathetic vasodilators / by H.H. Dale. Source: Wellcome Collection.

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    action which is entirely unrepresented in sympathetic innervation. I have weakened one of Cannon and Lyman’s difficulties by showing that vasodilatation can be produced, after ergotoxine, by direct splanch¬ nic stimulation. Their other chief objection—the “ known organisation of the autonomic system ”—can hardly be admitted as valid. Instances for a nerve supply of mixed function, from one source, are not wanting in this system, as, for example, the cranial autonomic innervation of the stomach through the vagus. Nor, apart from the cases which they rightly exclude as doubtful, are we without an independent example of vasodilators of true sympathetic origin ; the sympathetic supply to the coronary arteries1, the inhibitor effect of which is reproducer! by adrenine2, must, I imagine, be accepted as belonging to the true sympathetic system. There is, indeed, no good evidence, apart from that furnished by the action of ergotoxine, for a mixed motor-inhibitor sympathetic supply to arteries in general; but, this being the possibility under discussion, its non-existence cannot be postulated as a feature of the “ known organisation.” 1 Maass. Pfiilger's Arch, lxxiv. p. 281. 1899. 2 Langendorff. Zentralb. f. Physiol, xxi. p. 551. 1907. De Bonis and Susanna. Ibid, xxiii. p. 169. 1909.