The content of sugar in the blood under common laboratory conditions / by Ernest Lyman Scott.

  • Scott, E. L. (Ernest Lyman), 1877-1966.
Date:
[1914]
Catalogue details

Licence: Public Domain Mark

Credit: The content of sugar in the blood under common laboratory conditions / by Ernest Lyman Scott. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    least, in the nervous disposition of these animals and their prone- ness to excitement. Roily and Opperman^'^ discard them as entirely unsuited for such work. Seelig finds no glycosuria in one dog which had been bound for two and one-half hours. Roily and Opperman ^ also think that dogs may be safely used for such ex- periments, while Loewy and Rosenberg on the other hand find the concentration of sugar in the blood of both dogs and of rabbits increased by sensory stimulation, though, it is true, the increase in the dogs was not so marked. Boehm and Hoffmann first demonstrated glycosuria in cats as a result of binding them on a holder and so called it Fesselung Diabetes. This result has been interpreted as being due to various factors, as mental excitement, loss of heat, and muscular exertion. It has been shown in Cannon's laboratory that the first factor alone is sufficient. He therefore suggests the term emo- tional glycosuria. The general fact that hyperglycaemia and frequently glycosuria follow excitement in all laboratory animals, with the possible exception of the dog, and in man is widely ac- cepted. The only reason for adding to the already extended literature of the subject is to find to what extent the handling of an animal which is necessary for obtaining a sample of blood or in preparing it for an experiment may disturb the standard conditions. In my experiments, all animals in which excitement was evident were discarded, except as noted in the tables. A few in which excitement was evident were killed, and the results proved the necessity of Pavy's rule of complete tranquilhty if consistent find- ings are desired. Two animals, numbers 108 and no, were held, as if given ether by a cone, though ether was not actually given in either case. A third was placed in a bell jar for about the length of time that would ha,ve been required for etherization, had ether been given. Others were subjected to other conditions which are apt to occur in the laboratory and which produced sHght excite- ment, as indicated by crying or otherwise. The results, with a brief description of the conditions in each case, are given in Table 3. It will be seen that in every case there is a noticeable rise in the amount of sugar contained in the blood. These results show that the animal must be, as Pavy says, tranquil, not alone at the time that the sample is drawn, but for some time before. From