On the physiological action of ulexin / by J. Rose Bradford.

  • Bradford, John Rose, Sir, 1863-1935.
Date:
[1887?]
Catalogue details

Licence: Public Domain Mark

Credit: On the physiological action of ulexin / by J. Rose Bradford. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    persistent in its duration. Occasionally the effect on the kidney is a little more complicated, the injection being followed by a transitory expansion, lasting a few seconds; this being followed by a contraction, and finally the kidney expanding a second time. As regards the effects of Ulexin on the urinary flow, both the effect on the general blood pressure and on the kidney circulation would point to its being a diuretic, and this is what is found. In three successive observations made on the same dog under chloroform and curare, the following were the results obtained. Previously to the injection of the drug, the flow was at the rate of 3 drops a minute, after 10 mgrms. of Ulexin, the rate was increased to 12 a minute ; but this effect was only maintained for one minute. The flow then fell to 3—4 drops a minute, that is to say returned to normal; 50 mgrms. of Ulexin then quickened the flow to 9 drops a minute, at which rate it remained for two minutes. A second dose of 50 mgrms. then increased this rate to 12 per minute, and this was maintained for several minutes. Thus Ulexin is a powerful diuretic, as it quadrupled the urinary flow; but as is seen, the effect of small doses, such as 12 mgrms. is transitory, and it required as much as 100 mgrms. to maintain it for any length of time. Thus although the diuretic effect is quite as great, if not greater than that of caffein, the diuresis produced by the latter goes on for a much longer time. Further the doses of Ulexin necessary to main- tain the diuretic effect would kill through the Respiration. Thus Ulexin is an alkaloid, having a powerful and wide spread action, being a nerve and muscle poison, a respiratory poison, raising arterial tension and producing diuresis; but the respiratory action of the drug, being produced by the smallest doses, seems to be the most important.