An investigation into the pathology of pernicious anaemia / by William Hunter.

  • Hunter, William, 1861-1937.
Date:
[1888]
Catalogue details

Licence: Public Domain Mark

Credit: An investigation into the pathology of pernicious anaemia / by William Hunter. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    4. This condition of the liver serves at once to distinguish pernicious anaemia post mortem from all varieties of sym- ptomatic, anaemia, as also from the anaemia resulting from loss of blood. 5. The blood destruction characteristic of this form of anaemia differs both in its nature and its seats from that found in malaria, in paroxysmal haemoglobinuria, and other forms of haemoglobinuria. 6. The view can no longer be held that the occurrence of haemoglobinuria simply depends on the quantity of haemo- globin set free. 7. On the contrary, the seat of the destruction and the form assumed by the haemoglobin on being set free are im- portant conditions regulating the presence or absence of haemoglobinuria in any case in which an excessive disin- tegration of corpuscles has occurred. 8. In paroxysmal haemoglobinuria the disintegration of corpuscles occurs in the general circulation, and is due to a rapid dissolution of the red corpuscles. 9. In pernicious anaemia the seat of disintegration is chiefly the portal circulation, more especially that portion of it contained within the spleen and the liver, and the destruction is effected by the action of certain poisonous agents, probably of a cadaveric nature, absorbed from the intestinal tract. BALLANTYNE PRESS : TAVISTOCK STREET.