On intravascular clotting / by L.C. Wooldridge ; communicated by Professor Burdon Sanderson.

  • Wooldridge, Leonard Charles, 1857-1889.
Date:
1886
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Licence: Public Domain Mark

Credit: On intravascular clotting / by L.C. Wooldridge ; communicated by Professor Burdon Sanderson. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    135 On Intravascular Clotting. to coagulate, and when the quantity injected is insufficient to kill, the blood (drawn off after injection) may remain uncoagulated for some days. In either case coagulation of shed blood may be induced by the addition to it of the liquid which has been injected. It therefore appears that the agent which brings about coagulation, intra venas, -•nust disappear in the act of coagulation. The shed blood contains only a minute trace of fibrin ferment. The acetic acid precipitate is soluble* in 0'5 per cent. HCl solution. On digesting this solution at 37, after the addition of pepsine, a part of it is converted into peptone, but a precipibate appears in the pro- cess which is permanent. When the digestive products (peptone and precipitate), having been rendered alkaline, are injected into the circulation, no effect is produced.f There is neither intravascular coagulation, nor is the blood deprived of its power of coagulation ; but if fresh acetic acid precipitate be added to the liquid, both effects follow injection. Consequently, the failure of effect when the pro- ducts of digestion are injected alone, is not due to presence of pepsine or peptone. I have ascertained that the acetic acid precipitate does not cause coagulation of dilute magnesium sulphate plasma, which coagulates readily on the addition of fibrin ferment. The agent, therefore, in producing intravascular coagulation cannot be identified with that body. * As casein is soluble in milk. t The total quantity of peptone is \erj small. HAERISON AKD SONS, PEINTKE8 IN OEDINAET TO HEE ITAJESTY, ST. MAETIN'S LANE.