Resistance to infectious diseases : an exposition of the biological phenomena underlying the occurrence of infection and the recovery of the animal body from infectious dieease, with a consideration of the principles underlying specific diagnosis and therapeutic measures / by Hans Zinsser.

  • Zinsser, Hans, 1878-1940.
Date:
1931
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Licence: In copyright

Credit: Resistance to infectious diseases : an exposition of the biological phenomena underlying the occurrence of infection and the recovery of the animal body from infectious dieease, with a consideration of the principles underlying specific diagnosis and therapeutic measures / by Hans Zinsser. Source: Wellcome Collection.

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    PAGE tacks til disease. Kfforts at active imiimiii/.atinn. Protective bodies in serum. Protection by neutralized mixtures of convalescent serum and virus. Active immunization in Rocky Mountain spotted fever and in typhus fever. Agglutination of Proteus „\ 1!) in typhus fever. Im- munity in protozoan infections. Difliculties involved in the problem. Evidences of immunity in clinical observation. Persistence of virus ac compnnying increased resistance. Antibodies in protozoan infections. Adhesion phenomenon. Kvidences of phagocytosis. Alexin fixation. Kfforts at immunization. CHAPTER XXVI.—PRINCIPLES OF IMMUNIZATION APPLIED TO HUMAN DIS- EASES— IMMUNOLOGY OF IIIPIITH 1C HIA AND SOME OTHER EXOTOXIC Diseases—Tetanus; Snake Bite; Bacillus Botilinus; Welch Bacillus; Yjbkion Septique; Dysentery 527 Outline of methods of immunization used in human disease. Principles involved. Bacterial vaccines. Principles underlying proper production. Use of bacterial products for active immunization. Passive immuniza- tion in man. Difference in principle between antitoxic and antibacterial sera. Immunology of diphtheria. Mutation of diphtheria bacilli from smooth to rough. Diphtheria still a menace. Selective action of diph- theria toxin and sequence of symptoms in accidental diphtheria toxin in injury. Principles underlying use of antitoxin. Antitoxin in normal individuals. Duration of passive immunity. Principles of diphtheria antitoxin standardization. Concentration of antitoxin. Ramon’s floc- culation. Intracutaneous methods of measuring antitoxin. Active im- munization in diphtheria. T-A mixtures and anatoxin. Shiek reaction. Principles, methods, persistence. The use of tetanus antitoxin, thera- peutic and prophylactic. Antivenin. Different types of snake poison. Methods of use of antivenin. Serum treatment in botulismus. Anti- toxin against Welch bacillus. Antitoxin against vibrion septique. An- titoxin against cedematiens. Passive immunization iii Shiga dysentery. Chapter XX\ II.—Immunity in Scarlet Fever and in Other Strepto- coccus Infections. Immunity in Pneumonia 563 Immunological analysis of scarlet fever. Development of modern knowl- edge of etiology. Evidence supporting this etiology. Work of the Dicks and others. Problem of the specificity of scarlatinal strepto- coccus toxin. Relationship of scarlatinal to erysipelas toxin. Is there a heat susceptible exotoxin in streptococcus cultures? Hartley’s method of concentrating scarlet fever toxin. The Dick test. Active immuniza- tion with scarlet fever toxin. Scarlet fever antitoxin. Serum treatment in other streptococcus infections. Surgical infections. Erysipelas. Puerperal fever. Immunology of pneumonia. Basis of pneumococcus immunology. Pneumococcus types. Formation of serum autobodies in the disease. Possible reasons for ineffectiveness of late serum treat- ment. is there a rational basis for vaccine treatment in pneumonia? Prophylactic vaccination against pneumonia. Chapter XXVIII.—Immunity in Typhoid Fever. Immunity in Epi- demic Meningitis Immunological analysis of typhoid fever. Appearance of antibodies in typhoid and paratyphoid patients and relation to course of disease. Prophylactic vaccination in typhoid and paratyphoid. Principles under lying vaccine production. Therapeutic vaccination in typhoid fever. Serum treatment in typhoid fever. Immunology of epidemic menin- gitis. Incidence and carrier conditions. Susceptibility question. I’res ence of meningococci in the blood early in the disease. .Necessity for speed of serum administration and considerations of early diagnosis. Principles of serum therapy. Type classification. Failures of’'serum therapy due to aberrent types. Necessity for changing serum in such