On characteristic modes of fatal termination in multiple neuritis, with clinical and pathological investigation of an illustrative case / by G. A. Gibson and R. A. Fleming.

Date:
1895
Catalogue details

Licence: Public Domain Mark

Credit: On characteristic modes of fatal termination in multiple neuritis, with clinical and pathological investigation of an illustrative case / by G. A. Gibson and R. A. Fleming. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    the perineurium among the nerve fibres, many showing karyo- kinetic figures, and mostly grouped near the periphery of the funiculus. There is slight increase of connective tissue of the septa inside the funiculi. The fibres are apparently, to a great extent, normal towards the centre of the funiculi, those degenerated are mostly peripherally placed, although they are met with scattered here and there among healthy fibres throughout the funiculi. The axis cylinders show to a less Fig. 3.—Hsematoxylin and eosin (x 350). Right posterior tibial nerve. Transverse section. Shows lymphoid cells and also greatly enlarged axis cylinders. extent the changes described in the right posterior tibial nerve. Left sciatic nerve.—The changes here closely resemble those met with in the right sciatic, but in certain funiculi the lymphoid cells are in much greater numbers, and show better marked mitotic figures. There is also much greater proliferation of segmental nuclei, especially in certain funiculi, and in these the medul- lary sheaths appear much more degenerated, and more universally so. Some of the axis cylinders show great bulging or balloon- ing out. One in particular was observed fully twelve times