On the value of the bacteriological diagnosis of asiatic cholera / by Sheridan Delépine.

  • Delépine, Sheridan, 1855-1921.
Date:
[1894]
Catalogue details

Licence: Public Domain Mark

Credit: On the value of the bacteriological diagnosis of asiatic cholera / by Sheridan Delépine. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

    7/10 (page 5)
    in choleraic dejecta. Cunningham's observations have not, perhaps, received yet the attention which they deserve. The observations of Nicolle and Morax8 are perhaps not so well known. These observers found that the comma bacilli obtained from various sources did not only show differences of size and shape, but that some had four cilia or flagella (Mas- saowah, Calcutta, Paris, 1884), some had only one cilium (Shanghai, Hamburg, Paris, 1892; Angers, 1892), and in one instance it was impossible to demonstrate the existence of any cilium (Indian spirillum coming from Dr. Koch's labora- tory). It is interesting to note that the vibrios of Pinkler and Prior, Deneke, Gamaleia, and those found by Blachstein and Sanarelli in water have all only one cilium, like the second group of cholera vibrios mentioned above. Dr Kich- mond, working in my laboratory, has not been able to demon- strate more than one cilium in any of the spirilla I have isolated from the Manchester cases. It must be remem- bered that the cholera red reaction is a test important onlv in connection with spirilla isolated from the contents of the human intestine. The vibrio Metchnikovi gives the reaction and is pathogenic to guinea-pigs.8 It is even possible for the tinklers spirillum to acquire this property (Buiwid)10 These two facts I have been able to confirm. Quite recently, Blachstein11 and Sanarelli,12 Neisser 13 have described spirilla in water which are pathogenic to guinea- pigs, and give the cholera red reaction. Sanarelli's observa- tions seem to be most complete, and are extremely interest- mf t< -1S conclusions may be summed up as follows ■ 1. It is always possible to obtain from water contaminated with sewage spirilla having all the morphological cultural chemical, and pathogenic characters considered by Koch as diagnostic of the cholera spirillum. (Sanarelli obtained pathogenic spirilla from four different sources ) 0Dtamed me pathogenic water spirilla do not long retain their ffii?geXaPte°sPertieS' they alS° l0Se ^eS power ofPS ,3. It is possible to find in water spirilla mornholoeicallv similar to the cholera spirillum, but not paZ?en°c ?o tl e Slf f^'k t-h6Se are Pr0bably derived fr^ thf pathogenic hom ttiZ ^Tagt- t**™*™ f°™d spirilla in 5 ^^^i^S^JSf of these spirilla were seems to° W&^Tn °f Patho§enic spirilla in sewage Sta mdlcate that they are derived from intestinal ^lSo81SlsSWfhn0e*0f Spirilla obtained from a comZn 0r?gin nd °S6 f°Und m Water seems to indicate he^wnik0ffll-hasi0und comma bacilli./.i the stools of a EuWTl £TT m* the absence of any Solera epkiemic vtr^P ,had made Slmilar observations. Koch hirnsel? in S frf,8.' admjts the possibility of the pSnce of ^^X^it^^ Person! apparLSylShy