Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists.

  • Knoll AG (Ludwigshafen am Rhein, Germany)
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists. Source: Wellcome Collection.

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    nly a stationary condition. The majority of cases of cardiac ropsy, however, soon ran a favourable course, dropsy dis- ppearing, and subjective feelings rapidly improving. The »atients recovered with surprising rapidity and could again esume their avocations. As to the duration of the effect of the remedy after its Duration of Lse has been suspended, the investigations do not quite agree. We did see, though seldom, an increased quantity of urine mder such circumstances even 2—3 days as proved by actual ueasurement and chemical testing; in most cases we could lot determine the after-effect to last longer than 24 hours it the outside. Somnolence, a feeling of giddiness, head-ache and pro- Bye-Symptoms, 'use diarrhoea, were observed as bye-effects of the action of Diuretin; the same symptoms were recorded by Gram but pther authors reported that none were seen with the exception )f the diarrhoea. This last has little connection with the Diuretin treatment; we often saw it in chronic nephritis, as ilso, in cases of cardiac dropsy at a time, when the Diuretin :ure was not commenced. On the other hand, it must be icknowledged that in many cases, the diarrhoea disappeared with the suspension of the Diuretin; in most cases however t ceased of itself after a time and did not again appear. We ordered Diuretin, in powder form, up to 45 grains for heal¬ thy persons, who suffered from passing constipation, without producing any stools. It seemed, therefore, possible, that the remedy produced quite a different effect upon the sound and the diseased organism and that this is the case is proved by the fact, that, in healthy persons to whom Diuretin was given experimentally, we did not see — agreeing in that respect with Hoffmann — any increase in the quantity of urine. Somnolence and headache we saw only at the beginning and they were of but short duration; in cardiac dropsy ex¬ ceedingly rare. The urine, the specific gravity of which as the tables Quality of urine, show, corresponded to the volume, had few characteristics. The albumen-content was various; in cases of cardiac dropsy where the quantity of albumen mostly did not reach any high level, there was no noteworthy alteration; the quantitative albumen-estimation, according to Esbach, exhibited no diffe¬ rence worth mentioning. In referring to the cases of nephritis, we must distinguish Nephritis, between the acute and chronic forms. In the first, Diuretin proved to be without effect, but in the chronic variety, par¬ ticularly in the secondary shrivelling of the kidneys favour¬ able, nay sometimes astonishing, results, were obtained.