On the action of carbolic acid, atropia and convallaria on the heart : with some observations on the influence of oxygenated and non-oxygenated blood, and of blood in various degrees of dilution / by H.G. Beyer.

  • Beyer, Henry Gustav, 1850-1918.
Date:
[1884]
Catalogue details

Licence: Public Domain Mark

Credit: On the action of carbolic acid, atropia and convallaria on the heart : with some observations on the influence of oxygenated and non-oxygenated blood, and of blood in various degrees of dilution / by H.G. Beyer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    7/28 page 79
    periority of defibrinated blood and Ringer’s solution mixed in eqiral volumes, that I used this mixture in all subsequent ex- periments. The Influence of Oxygenated and Non-oxygenated Blood upon the Work of the Heart. One of the first to investigate the influence of different gaseous substances on the isolated heart of cold-blooded animals was Castell {Arch. f. Anat. u. Physiol. 1854, p. 226). According to this observer the heart of the frog, when cut out and placed under a bell glass, would on an average continue to beat for three hours, the ventricle ceasing its contractions long before the auricles. In rarefied air the heart beat only for thirty minutes. In an atmosphere of oxygen the heart was found to beat for twelve hours; surrounded by carbon dioxide gas, the contractions continued only six minutes ; they were, however, resumed on the admission of air, and then continued for two hours. Cyon {Comptes Rendus, 1867), from some experiments made in the laboratory at Leipsic under Prof. Ludwig, came to the following conclusions: “ Mes experiences ont demontre que l’oxygen excite surtout les ganglions moteurs du coeur tandisque l’acide carbonique agit de la meime maniere sur les ganglions regulateurs.” McGuire {Arch. f. Anat. und Phys. 1878, p. 321), working under Kronecker’s direction, arrived at the conclusion that oxygen exerted no perceptible influence on the heart’s action, while carbon dioxide weakened it very much. A year later Klug {Arch. f. Anat. u. Phys. 1879, p. 435) published a number of experiments on the influence of oxygen and carbonic acid upon the frog’s heart. The conclusions arrived at were, that oxygen very much increased both the intensity and the frequency of the heart’s beat, while carbonic acid had the opposite effect. His experiments, therefore, were in perfect agreement with those of Castell made nearly twelve years previously. Some years later, Klug in connection with Desiter Velits undertook the same line of research on the mammalian heart. The gases were admin- istered through the lungs, by means of an apparatus for artificial respiration which was in connection with gasometers containing oxygen and carbon dioxide gas respectively. It was found that in animals with divided spinal cord and vagi a 40 per cent, car-
    digitised image 1
    digitised image 2
    digitised image 3