On the characters, actions, and therapeutic uses of the ordeal bean of Calabar, (Physostigma Venenosum, Balfour) : a graduation thesis, for which a gold medal was awarded by the Edinburgh University, August 1862 / by Thomas R. Fraser, M.D.

  • Fraser, Thomas R. (Thomas Richard), 1841-1920.
Date:
1863
Catalogue details

Licence: Public Domain Mark

Credit: On the characters, actions, and therapeutic uses of the ordeal bean of Calabar, (Physostigma Venenosum, Balfour) : a graduation thesis, for which a gold medal was awarded by the Edinburgh University, August 1862 / by Thomas R. Fraser, M.D. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    C. Modified Actions, I. WITH BOILED KERNEL. Experiment 26.—Twenty grains of powdered kernel were boiled for two hours with distilled water, and placed in a cavity in the subcutaneous cellular texture of a, rabbit. A few struggles foUowed the introduction; tlie breathing became rapid; and the rabbit fell down in four minutes. The pupils contracted: very teeble struggles occurred when the rabbit was lifted; and it remained in any position. In six minutes, the reflex function of the eyelids was lost, and in seven the respirations had ceased. Autojjsy—immediate.—The pupil dilated during the opening of the chest ihe heart was found passive and distended. All its chambers contained blood and the difference m colour between the riglit and left sides was strongly marked. Ihe vermicular action of the intestines was very feeble. The sciatic and phrenic nerves were pricked without any effect. No congestion was seen ot any viscus The mesenteric arteries and veins were distinctly different m colour. The abdominal aorta and venaj cavje contained blood of normal colours The stomach and bladder were full. Rigor mortis began in one W aj^plicatlo? ^ '^'''''^ appearance was found in the region of II. WITH THE BEAN BOILED ENTIRE. • i^^'^NT 27.-An entire bean, weighing seventy-two grains was boiled Inimn ^ater for four hours. The kernel was then separated ?™m he fepeimodei-m, and found to be of a brownish colour. One cotyledon weSw p obably twenty-eight grains (the other having been dried Ld fouiufto bf l^ofrfSl^i-orrabbi? No effects were observed till twenty minutes, when the rabbit beean to move Its jaws, and to grind its teeth as in chewing. In fifty minutes flu d feces were passed, and in an hour the pupils were slightly coi trfct^d Ve v fluid faeces and urine were now frequentlyf almost incessa^tlTvo'ded Voi two ZJs T'')^ ^^'^ diminislied, and entirely di appea ed in five houis after the administration. No effects remained six hours afterwards. III. WITH STRYCHNIA AND PHYSOSTIGMA Experiment 28 -Three-tenths of a gi-ain of strychnia Avere sprinkled « recent wound m the left flank of a n.ongrel dog. The animal stumKlpd Tn^ Almost immediately afterwards the spasms ceased in the left limh ar,^ • short time in tlie right also. In three minutes aftpr tL-<f - • ^ ^ action could not be excited in the poste t eXmitts TZ '^^'^ dilated, and clonic spasms frequen ly recurred in tl.i n . • ^''P'^' remained trunk In seven minutes, thT e S^^^^^ were found pointing upwards and outwards. Cmurcukr aE \p n ^J-' Uie posterior extremities, but slight spasms were ob eiwed n a ok?^ The ammal died twenty minutes'-after^tlie administrS of tn c?m a &ij^Mj%j|;sf^