Prader Willi & Angelman's syndromes - probes

Human chromosome highlighted by fluorescent probes that bind to specific sequences of DNA. This FISH (fluorescence in situ hybridisation) study uses a probe (red) from the Prader Willi and Angelman's syndromes critical regions (PWASCR) and a centromere specific probe for chromosome 15 (green) to show that this 15q11.>q13 duplication does not include the PWASCR. Image by Dr John Crolla