Genetics : genetic information and the control of protein structure and function transactions of the first conference October 19, 20, 21, and 22, 1959, Princeton, N.J / edited by H. Eldon Sutton.

  • Macy Conference on Genetics 1959 : Princeton, N.J.)
Date:
[1960]
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Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetics : genetic information and the control of protein structure and function transactions of the first conference October 19, 20, 21, and 22, 1959, Princeton, N.J / edited by H. Eldon Sutton. Source: Wellcome Collection.

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    Index 223 Helices four-stranded, 53 three-stranded, 53 Heme-heme interaction, 73, 74 Hemoglobin. See also Hemoglobins accumulation of, with reticulocytes, 118 adult, 67, 68, 69, 113, 140, 163 lack of isoleucine in, 142 Alexandria, 163 Bart's, 68, 153 chemistry, 67f. composition of, 163-164 denaturation of, 74-75 dissociation and reassociation of molecules of, 98, 136-138f. as early gene product, 65 heme groups of, 73 heme-heme interaction, 73 minor normal components of, 67, 68-69, 99, 146, 147 molecule of, 69, 70 mutations, 149 in newborn infant, 67-68 normal types of, 168-169 notation for hemoglobin genes and gene products, 100, 101 polypeptide chains of, 71-73, 97 primitive, 68, 113, 140, 168 as protein made in particular cell, 65 reconstituted, 76 regeneration of, 78 sickle-cell anemia, 66 as standard protein for study, 66-67 symmetrical arrangement of chains in, 69-70 treatment of, with acid-acetone, 76 wild type, 67 X-ray structure of, 71-73 Hemoglobin A, 67, 136, 137, 142, 154, 165, 169 chains of Ag, F and, identical, 162 fingerprints of trypsin digests of, 86, 87, 88 hidden variability of protein struc¬ ture and hidden mutations and, 89 Hemoglobin—Co77td. molecular weight of, 69 nonelectrophoretic mutations in, 166 peptide chains in, 69 proline in chains of, 69, 70 and S, 82 and thalassemia, 140, 170 and thalassemia major, 148 and thalassemia minor, 148 Hemoglobin A2, 169, 146, 147 chains of hemoglobin A, F and, identical, 162 genotype of, 148 in hemoglobin H patients, 151 starch block analysis of bloods illustrating, 147 in thalassemia major, 148 in thalassemia minor, 148 Hemoglobin C, 67, 136, 137, 142, 164 mutation, 97-98, 113 pedigree of mating of sickle trait carrier with double heterozygote for, and high fetal gene, 159 and S mutations allelic, 91 thalassemia, 149 Hemoglobin D, 67, 164 from different subjects, 87 fingerprint of trypsin digests of A and, 87, 88 Indians affected by, 90 and mutation, 89 and S, 90 thalassemia, 149 Hemoglobin E, 67, 164 chemical effect of mutation on, 96 Peptide No. 26 in, 96 thalassemia, 149 Hemoglobin F, 67-68, 143, 153, 163, 164, 165, 168, 169 in adults, 84 chains of, 140-141 chains of A2, A and, identical, 162 duration of, 67 fingerprints of chains of, 141