Atherosclerosis : an introduction to atherosclerosis.

Date:
1975
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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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Credit

Atherosclerosis : an introduction to atherosclerosis. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Source: Wellcome Collection.

About this work

Description

Dr Barry Lewis, Professor Neville Woolf and Professor Colin Adams discuss atherosclerosis. In this particular lecture they introduce the basic factors of atherosclerosis - how it manifests itself in various forms of cardiac crisis such as heart attack, angina or sudden death; how it can be prevented and what its main causes are thought to be. 6 segments.

Publication/Creation

London : University of London Audio-Visual Centre, 1975.

Physical description

1 encoded moving image (38.38 min.) : sound, black and white

Duration

00:38:38

Copyright note

University of London

Terms of use

Unrestricted
CC-BY-NC
Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

Language note

In English

Creator/production credits

Presented by Dr Barry Lewis, Department of Chemical Pathology, Royal Postgraduate Medical School; Professor Neville Woolf, Department of Histopathology, Middlesex Hospital Medical School; Professor Colin Adams, Department of Pathology, Guy's Hospital Medical School. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

Notes

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Contents

Segment 1 The opening credits show city streets, pollution, cigarette smoking, frying food, the measuring of a lump of skin fat, a blood pressure gauge, cholesterol molecules and a crowd with a chunk of people obliterated from it. Dr Barry Lewis talks to camera. He introduces the subject saying that atheroscloerosis can cause myocardial infarction, angina pectoris and sudden death. He shows a chart detailing the mortalitiy statistics of heart disease in the UK which has risen over the last 40 years. He shows a graph based on studies by Ancel Keys into the relationship between diet, cholesterol and heart disease. Lewis introduces Professor Neville Woolf. Woolf shows a photograph of an atherosclerotic artery and explains how its appearance allows us to recognise atherosclerosis. He then refers to a diagram showing the progress of atherosclerosis over a lifetime. Time start: 00:00:00:00 Time end: 00:07:44:00 Length: 00:07:44:00
Segment 2 Woolf refers to a series of slides showing microscopic depictions of various atherosclerotic lesions within different arterial locations. He describes the pathology of each of them in much depth. Time start: 00:07:44:00 Time end: 00:12:25:00 Length: 00:05:19:00
Segment 3 Woolf shows a chart listing features which lead to a coronary clinical event; he is keen to point out that atherosclerosis alone is not the only contributing factor involved in a serious coronary event. He introduces the subject of the atherosclerotic plaque and invites Professor Colin Adams to talk further about it. Adams describes, using charts and graphs, how arterial lipid accumulations (cholesterol) can lead to the development of plaques over time and atheroscleroma scarring. He hands back to Woolf to discuss this further. Time start: 00:12:25:00 Time end: 00:17:40:00 Length: 00:05:15:00
Segment 4 Woolf discusses the link between atherosclerotic plaques and thrombosis, he shows slides to illustrate what these look like. He refers to an experiment in which an artificial thrombus was produced on an arterial wall; he shows slides detailing the results of this experiment performed on a pig's artery. Time start: 00:17:40:00 Time end: 00:22:32:00 Length: 00:04:52:00
Segment 5 Lewis returns to camera. He discusses the links between lipid levels and atherosclerosis. He discusses his own work comparing lipoprotein concentrations in blood plasma with those in the arterial wall, then shows a diagram which explains how lipoproteins can enter the arterial wall. He explains some of the known barriers which keep cholesterol from damaging the arteries. He invites Woolf to talk further about endothelial injury - the endothelium being the thin layer of cells lining an artery. Time start: 00:22:32:00 Time end: 00:30:08:00 Length: 00:07:36:00
Segment 6 Woolf talks about things known to damage the endothelium such as cigarette smoking and poor diet; he describes how this happens then hands back to Lewis. Lewis shows a slide which compares the results of an experiment in rhesus monkeys with atherosclerosis, before and after a cholesterol-reducing diet. Finally, all three speakers are seen sitting around a table whilst Woolf addresses the camera and advises caution in making too strong a connection without enough evidence to the connection between arterial wall disease and cardiological clinical events. Time start: 00:30:08:00 Time end: 00:38:38:15 Length: 00:08:30:15

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