The effect of intraperitoneal injections of ozone in animals following injections with virulent bacteria / by S.E. Finch.

  • Finch, S.E.
Date:
1914
Catalogue details

Licence: In copyright

Credit: The effect of intraperitoneal injections of ozone in animals following injections with virulent bacteria / by S.E. Finch. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    centration of ozone is to cause an increase in the amount of anesthetic necessary; but after use for five minutes or longer this effect is no longer ob- served. The introduction of ozonized air, the ozone rep- resenting ten times the foregoing concentration, i. e., 0.008 to 0.01 per cent, by weight, into the peri- toneal cavity, causes very rapid respirations; and if the pressure is increased as by the use of dis- tention, respirations become so rapid that respira- tory pauses of one to four seconds punctuate them. The heart action likewise becomes very rapid, but shows no arrhythmia unless the respirations are embarrassed. There is no increase in the amount of anesthetic required while using this gas, and a stupor or semiconscious state exists for one hour or longer after discontinuing the anesthetic when 100 milligrams or more of the ozone have been used. Aside from this action on respirations and heart, there occurs a slight grade of hemolysis in the general circulation following the use of this number of milligrams or more of the gas. This is noticed in the serum of blood drawn from the ear of a normal animal after use of the gas, and, while only of a slight grade, still awaits accurate expla- nation. With still higher concentrations of ozone, as the use of 0.015 per cent., oxygen dilution, the intro- duction of but 190 to 200 milligrams without bal- looning the abdomen, causes death of a normal ani- mal within six to eight hours of its use with symp- toms as described above. The use of ozone gas within the peritoneal cavity of animals following general peritoneal infection, may be without harm to the animal if the concen- tration is very weak, not greater than 0.001 per cent, by weight and in oxygen dilution. Under the following conditions the animals survive the use of a continuous current of 0.001 per cent, ozone: Use within three hours of a general peritoneal infec- tion, limitation of the infection to the peritoneum,