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DNA sequencing autoradiograph - coloured
- Michele Studer
- Digital Images
- Online
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Attribution 4.0 International (CC BY 4.0)
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Credit: DNA sequencing autoradiograph - coloured. Michele Studer. Attribution 4.0 International (CC BY 4.0)
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Description
Di-deoxy sequencing is a way to determine the
order of bases (A,C,G and T) in a piece of DNA.
Using a DNA polymerase, a new strand of DNA is
made from the existing strand in a test tube. By
incorporating a radioactive label and a mixture of
bases, some of which stop the new chain when they
are randomly inserted, many new strands of
different lengths are generated. These can be
separated by electrophoresis on an acrylamide gel
and the sequence of bases worked out.