Human stem cell embedded in a 3D matrix, Cryo SEM.

  • Ferreira, Silvia A.
Date:
2015
  • Digital Images
  • Online

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Attribution 4.0 International (CC BY 4.0)

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Human stem cell embedded in a 3D matrix, Cryo SEM. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.

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Description

False-coloured cryogenic scanning electron micrograph (Cryo-SEM) of a single human stem cell (centre of image) embedded within a porous hydrogel matrix. The structure and properties of the hydrogel matrix were designed to mimic those of the cell's native environment in the bone marrow. Imaging stem cells in a 3D environment provide valuable insight into the bidirectional physical interactions between a stem cell and its 3D niche. The hydrogel is composed of thiolated hyaluronic acid cross-linked with poly(ethylene glycol) diacrylate. The diameter of the cell is approximately 15 micrometres. Scanning electron micrograph 2015

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2015.

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