On some non-specific reactions of mallein / by H.J. Südmersen and A.T. Glenny.

  • Südmersen, Henry J.
Date:
[1908]
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: On some non-specific reactions of mallein / by H.J. Südmersen and A.T. Glenny. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    number of months of treatment, description of toxin or organism used, and the number of days since the last injection. It need hardly be added that none of these horses reacted to mallein before treatment, no horse being introduced into the stables unless it has satisfactorily passed the test. It will be noticed that a large number of these horses gave decided local swellings. An analysis of the results shows that the size of swelling in general depends on the degree to which the horse has been immunised. In the following tables the reactions are divided as follows:— Large reaction. Well-defined sharp swellings over 3x3 or ill- defined swellings over 4x4 (inches). Medium reaction. Any well-defined swelling under 3x3; an ill-defined swelling of 4 x 4 or any swelling not dispersing rapidly. Small reaction. Any ill-defined swelling under 4x4 dispersing rapidly. Horses immunised against Diphthena Toxin. In Table II the results are tabulated for all horses that have been used solely for the production of diphtheria antitoxin serum. TABLE II. Horses injected with diphtheria toxin, grouped according to length of immunisation. Number of months under treatment 1—6 Large reaction Horse 53 Medium reaction Horse 3 35 Small reaction Horse 9 17 18 52 Total 1 2 4 7—12 Horse 23 _ Horse 15 36 — — Total 2 0 1 Over 12 Horse 19, 26 38, 40 — — 47, 48 — — 59 — — Total 7 0 0 From this table it will be seen that all horses that have been immunised with diphtheria toxin for over twelve months give large local