The crescent forms of the erythrocyte in normal and pathologic blood expressions : origin of red blood corpuscle and blood plasm / by Frank A. Stahl.

  • Stahl, Frank August, 1862-
Date:
[1887?]
Catalogue details

Licence: Public Domain Mark

Credit: The crescent forms of the erythrocyte in normal and pathologic blood expressions : origin of red blood corpuscle and blood plasm / by Frank A. Stahl. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    teiied elongated ones have often been interpreted as endothelial inclined; but not so, they are nuclei from the second row under- going differentiation now into the spindle or elongated form from the large round nucleus with several nucleoli; where the nucleus has developed into now two small off's])ring still clinging together in elongated form, soon to break apart on their way towards hematinization and erythroblast formation in the blood stream. Such elongated or spindle-shaped nuclei are seen in the villus stroma between the edge of the blood vessel and the second row of the villus. Illustration of intra-connective tissue differentiation. Explanations of FigupvES 9 and 10. Fig. 9.—Sickle-cell erythrocytes in sickle-cell anaemia ; nucleated and non- nucleated forms. Illustration not text from Dr. V. P. Sydenstricker. Jour. Amer. Med. Ass. 1924. 6— 'Nucleated sickle-cell. 7— Non-nucleated sickle-cells. Disappearance of nucleus in blood corpuscle differentiation, from nucleated to non-nucleated erythrocyte ; here each step is clearly and plainly shown, an exceptional illustration for this purpose. Differentiations are alike in the normal and pathologic. 1— Nucleus of erythrocyte wanders to edge of its cell. 2— Just ready to extrude nucleus into general blood stream. 3— Nucleus rests loosely in the cell cavity as though moment just before casting off. 4— Peiipheral cell cavity as though just emptied of a nucleus. 5— Many nuclei-whole-extruded into the general blood stream. Finally, the many iierfect non-nucleated erythrocytes disseminated through- out the general field. Use handglass. Fig. 10.—Cross section of blood vessel from villus near attached one to decidua described in Figure 2. 1906; Vessel margin, no endothelium; content, mono-nucleated erythroblasts ; erythroblasts in stroma of villus; observe nuclei wandering from second row. several empty space effects there ; several coarse multinucleated nuclei in rim of blood vessel. 1. Darge second row nucleus wandering into blood space-vessel; with large handglass, this nucleus appears to have several nucleoli as though ready to break up into several offspring, future erythroblasts ; others around edge ; no endothelium ; this picture probably affords another explanation of fonner theory, that iirolifeiation of endothelium gave origin to red blood corpuscles. This no endothelium feature of this blood space-vessel is seen throughout early blood-vessel expression, even in the important umbilical arteries and vein of the umbilical cord of the .5-6th week ; where no endothelium is again the pic- ture and the rule. The two flattened cells in lower edge of lumen are elongated spindle-shaped nuclei, dividing into several offspring; but not endothelial inclined. 2. Note second row nuclei seem directed inwards toward stroma of villus, e.specially at 2 ; showing principle of direction and activity. .3. Empty spaces suggesting departed nuclei. 4. Empty space with nucleus just below ; nucleus aiipears dividing into two offspring. .0. Darge nucleus about to divide. 6. Position of nucleus in the erythroblast suggests ease of nucleus extru- sion from cell in differentiation to the off.spring, the ei*ythrocyte; extrude the nucleus, there is left the cup-shaped cre.scent form for further differentiation. In the noiTnal casting off. see Fig. 2 above.