A preliminary report on 120 cases of tuberculosis treated with the Friedmann vaccine / by Harry Lee Barnes.

  • Barnes, Harry Lee, 1877-
Date:
1913
Catalogue details

Licence: In copyright

Credit: A preliminary report on 120 cases of tuberculosis treated with the Friedmann vaccine / by Harry Lee Barnes. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    infected and that this infection descended to the epididymis in this as in other cases. A guinea pig inoculated with urine on July 18th had not developed recognizable tuberculosis when killed on August 23rd, while another guinea pig inoculated with fluid massaged from the prostate on the same day did not develop tuberculosis. Further evidence against the vaccine having infected the epididymis is found in the fact that pus from the epididymis infected a third guinea pig, which was killed on August 26th. The liver, spleen and omentum appeared tuberculous, and sections of tissues prepared and examined by Dr. Sawyer showed typical tuberculosis. A control animal remained healthy and was found free from tuberculosis at autopsy. Class B. Showing Usual Improvement After the Vaccine Treatment. Case No. 2026. E. C., Female, age 24. Frequent micturition since childhood. Hematuria at 12. In this institution with pulmonary tuber- culosis April 28, 1908, to June 18, 1909. Hematuria once while in the Sanatorium. Tuberculosis of bladder diagnosed at that time by cysto- scope. T. B. found in urine. Lung disease arrested, bladder improved. Again a patient here mainly because of bladder disease, July 22 to Octo- ber 22, 1912. Between the time of returning home in October, 1912, and March, 1913, had hematuria three or four times. Readmitted March 3, 1913. A few subcrepitant rales to 2nd rib on both fronts. Sputum only 3 c. c. and lung disease evidently not very active. No T. B. in sputum. Temperature normal. Pulse 87. Urine shows light cloud of albumen. Hundreds of pus cells to a high power field. Urina- tion about 24 times in 24 hours. One or two days a week, has sharp pains lasting several minutes after urination. On other days free from pain. March 16th. Slight hematuria. April 9th. First injection of vaccine. No reaction followed. May 28th. Second injection of vac- cine. Capacity of bladder averages 60 to 90 c. c. June 8th. Pain in bladder unusually severe and practically every day since 2nd injection. July 13th. Indurations at site of both injections have been present con- tinuously since shortly after second injection. July 28th. Patient has gained five pounds in weight. Has had no hematuria since March. Urine contains T. B. and a hundred pus cells to a field. Micturition about the same as before admission. Pain in bladder rather more than usual. The following records are from the cystoscopic examinations of Dr. H. C. Pitts and his associate, Dr. I. H. Noyes, of Providence: “April 24. Cystoscopic examination. Bladder holds only about 4 oz. There is marked redness in nearly whole extent of bladder wall; just behind and to right of R. ureter mouth is a distinct ulceration having small blood clot attached. R. ureter mouth normal. On left, ureter mouth is contracted and surrounded by gray exudate; there is no visible ulceration. May 22. Cystoscopy shows some improvement in bladder. The grayish exudate around L. ureter mouth, however, is more marked and ureter mouth itself more contracted; no treatment given. July 2.