The toxicity of caffein : an experimental study on different species of animals / By William Salant and J. B. Rieger.

  • Salant, William, 1870-1943.
Date:
1912
Catalogue details

Licence: Public Domain Mark

Credit: The toxicity of caffein : an experimental study on different species of animals / By William Salant and J. B. Rieger. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    Table 9.—Subcutaneous injection; cats—Continued. SERIES D. Num. ber- Weight. Caffein per kilo. Symptoms. Duration of life. 13 Orama. 730 1,165 965 1,605 1,625 2,335 2,710 1,785 2,315 2,325 Oram. 0. i;w .138 .103 .125 .125 .128 .129 .123 .112 .120 Restlessness 21 None 25 do 26 do 27 do 28 do 40 do Do. 41 do Do. 42 do Do. 38 Mild SERIES E.i 3,225 3,050 4,220 4,250 0.124 .118 .084 .084 40 minutes. Died soon after. Survived. 2 hours. Pathological conditions. * Two days after first injection. Table 10.—Injections into peritoneal cavity; cats. Num- ber. Weight. Caffein per kilo. Symptoms. Duration of life. 99 Qrams. 3,000 4,100 1,450 2,615 505 575 860 790 2,970 2,420 Oram. 0.100 .100 .137 .145 .200 .139 .200 .200 .200 .183 Mild Survived. Do. Do. Do. 5 days. 6 days. 30 minutes. Survived. 1 hour. 30 minutes. 98 do.i 93 Very mild 87 ..do 97 None 96 ..do . 95 15 minutes 94 10 16 1 In few minutes. Table 11.—Administration of caffein by mouth; cats. No. Weight. Caffein per kilo. Symptoms. Duration of life. 91 Qrams. 3,050 3,260 1,750 2,620 2,685 2,860 2,450 2,740 1,640 Oram. 0.15 .15 .16 .15 .20 .20 .15 .124 .125 1 hour 40 minutes 2 hours. 88 1 hour 40 minutes. 92 2) minutes Survived. 87 3 hours Do. 90 1 hoiu 15 minutes Loss than 18 hours. 89 75 minutes. 82 Less than 24 hours. 100 1 hour 40 minutes Survived. 93 Do. SUMMARY. The toxicity of caffein in cats is shown to be the same when given by mouth as when injected subcutaneously, the minimum fatal doses in both cases being 0.15 gram per kilo. When introduced by the intraperitoneal route, caffein is, on the contrary, distinctly less toxic. After the administration of 0.137 and 0.145 gram