Type I collagen with proteoglycans

  • Rob Young
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Type I collagen with proteoglycans. Rob Young. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Source: Wellcome Collection.

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Transmission electron micrograph showing collagen fibrils in the human sclera. This sample has been treated with a cationic dye to reveal dermatan/chondroitin sulphate proteoglycans attached to type I collagen fibrils. These proeteoglycans are visible as the small projections along the sides of the larger collagen fibrils. The a-e repeat periodic banding pattern is also clearly seen in these fibrils. The fibrils are approximately 130-210 nm in diameter.

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