Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan.

  • Bolduan, Charles, 1873-1950.
Date:
1908
Catalogue details

Licence: In copyright

Credit: Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan. Source: Wellcome Collection.

    180/218 (page 164)
    APPENDIX B. NOGUCHI’S BUTYRIC ACID TEST. Feeling that the lecithin, glycocholate of soda, oleate of soda, and other compounds which had been used in the various modifications of the Wassermann test, might act as acids, and that this acidification possibly gave rise to a precipitate of globulins and related substances, Noguchi sought to discover the nature of the Wassermann reaction by studying the influence of various acids on the serum of different individuals. He found that in general a greater degree of precipitation was pro- duced in syphilitic sera than in non-syphilitic ones. It was natural to think that the deflection of com- plement observed in the Wassermann test was due to adsorption by the precipitate as such, but on testing the precipitate itself this was found not to be the case. The increased precipitation produced in syphilitic sera by the addition of acid suggested an increase and qualitative change on the part of the serum globulin, and this possibility was also indicated by the results obtained by Klausner. This author, it may be stated, devised a test for syphilis, based on the formation of a precipitate when the scrum