Mystery to mechanism.

Hydrochloric acid experiment; Gastric acid controversy; 18th C. discovery of PH indicators confirmed existence of gastric acid. Dramatic reconstruction of test for acidity of gastric juice. Dramatic reconstruction - Prout writing his Royal Society paper, 1823. Lake Huron - NW Frontier - Dr. Beaumont studied gunshot wound of St. Martin for gastric physiology. 1930 - Dodds and Robertson proved that hydrochloric acid was the only acid produced by the stomach. Parietal cell (model) produces acid. 1902 - Pavlov (photographs with dog) traced secretion of gastric acid. Sir Henry Dale (photograph) found that histamine also stimulated parietal cell. Sir James Black - discovered H2 receptor. H2 led to drugs for treatment of peptic ulcer. The acid pump (shown on model). 1974 - synthesis of timporazol. 1979 - meprazol, for ulcers (inhibits the acid pump)