Collected papers on pharmacology and therapeutics.

  • Phillips, Charles D. F. (Charles Douglas Fergusson), 1830-1904.
Date:
1908
Catalogue details

Licence: In copyright

Credit: Collected papers on pharmacology and therapeutics. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

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    phate contained in urine and phosphatic calculus, even when primary, is almost entirely formed within the bladder. These views, as they are not in accord with commonly received clinical evi- dence, require confirmation, but they suggest moderate expectation of cure by calcium salts. The bicarbonate is soluble by virtue of the ex- cess of carbonic acid and is readily absorbed. The neutral carbonate in small doses (five or six grains) is soluble in the gastric juice, and is absorbed as chloride. The chloride itself in similar dose, and even up to fifteen or twenty grains, diluted suf- ficiently to disguise its caustic taste (as with three ounces of sugared water), is absorbed without gastric disturbance, and is rapidly excreted by the kidneys ; larger doses cause a sense of oppression,, with nausea and diarrhoea. According to Perl, the chlorine passes in the urine, the lime mostly in the faeces. Unduly large doses of lime-water, or of phosphates or carbonates, may cause gastro- intestinal irritation. Of that which is absorbed an equivalent quantity is eliminated, except during the period of growth, and especially of bone development. There seems to be a power of laying by some of the substance for this purpose, e.g., during the early months of pregnancy when bony growths (osteophytes) sometimes form in the bone of the parent, which diminish with the growth of the foetus. The excreted calcium is found in the