Collected papers on pharmacology and therapeutics.

  • Phillips, Charles D. F. (Charles Douglas Fergusson), 1830-1904.
Date:
1908
Catalogue details

Licence: In copyright

Credit: Collected papers on pharmacology and therapeutics. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

    164/288 (page 152)
    THE ACTION OF THE LIME SALTS. The various salts of calcium differ somewhat, not only in the powers of absorption but also in their pharmacological action. The tribasic and neutral phosphates, in small doses (less than five or six grains), when administered with but little water, are wholly absorbed by the acid gastric secretion ; but if given with much water, the acid is so far diluted that it does not act upon the insoluble drug, which then passes off mainly by the fasces. Raudnitz concluded that absorption occurred chiefly in the intestines, especially the duodenum, but when large doses are given the greater part passes unchanged. Gourlet has suggested that the solubility necessary for securing the absorption of calcium phosphate is effected partly by means of the sod- ium phosphate contained in the saliva, partly by the ammonium phosphate and the acids in the stomach, and when it has passed into the veins solubility is still further assisted by the carbonic acid present in venous blood. During respiration, when carbonic acid is given off and lactic and other acids are altered, the phosphate that has been taken is retained in solution only by the help