Observations of morbid changes in the mucous membrane of the stomach / by Handfield Jones ; communicated by Bence Jones.

  • Charles Handfield Jones
Date:
1854
Catalogue details

Licence: Public Domain Mark

Credit: Observations of morbid changes in the mucous membrane of the stomach / by Handfield Jones ; communicated by Bence Jones. Source: Wellcome Collection.

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    the surface is often absent in parts where there is much inter-tubular formation, and the nucleated fibroid tissue is then exposed. It may, however, have been covered in by the columnar epithelium during life. 4. The tubes appear, in some instances, to decay spon- taneously, or, at least, not from the atrophic pressure of new formed fibroid tissue; the mucous membrane may then pre- sent a mere mass of granular and celloid debris, with inter- spersed fat vesicles and fatty matter. 5. Black pigment may be deposited in the mucous tissue sometimes in great quantity; it is occasionally within the tubes, more often between them. It appears in the form of granules and masses. In other cases yellow pigment is to be found. Both are to be regarded as proceeding from altered hsematine. 6. Cystic formation is occasionally met with; it seems to take place in three ways : (1.) A nuclear mass liquefies, and leaves a cavity which is occupied by a clear fluid. (2.) While atrophy of the tubes is taking place, a portion of one becomes distended into a cystic cavity. (3.) A cyst is produced (de novo) as a large vesicle, a true new formation. 7. Mammillation is often seen in lesser degrees, and not unfrequently well marked. It affects especially the pyloric third or half of the stomach. To obtain a good view of it, or indeed not to overlook it, it may be absolutely necessary to wipe off a thickish layer of tenacious adhering mucus. It seems to be of two kinds, or to be produced in two ways. One may be called healthy, and appears to depend on some unusual contraction of the corium of the mucous membrane. That this may take place is very intelligible from the cir- cumstance stated by Middeldorpf, and confirmed by Kolliker and Briicke, that there exist numerous organic muscular fibres in this layer. I have observed that this mammillated appearance is produced in some specimens in a very marked manner, or, if not entirely produced, rendered much more striking by immersing the mucous membrane in water, or in dilute acid, which seems to have a constringing action on some of the component tissues, probably the corium. The
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