Upon the properties of an antityphoid serum obtained from the goat / by Allan Macfadyen, M.D. ; (communicated by Dr. C.J. Martin, F.R.S. Received March 2, - read March 8, 1906.).

  • Macfayden, Allan, 1860-1907
Date:
1906
Catalogue details

Licence: In copyright

Credit: Upon the properties of an antityphoid serum obtained from the goat / by Allan Macfadyen, M.D. ; (communicated by Dr. C.J. Martin, F.R.S. Received March 2, - read March 8, 1906.). Source: Wellcome Collection.

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    goats, and to carry out the process in a still more careful manner. The method adopted is given in the following schedule :— Nanny Goat II. — Received following intravenous injections of toxic cell juices of B. typhosus— 1905. 1905. Oct. 13 .... ... 1/20 c.c. Ill. Dec. 22 .... .. 1/8 c.c. No symptoms. „ 20 .... .. 1/20 55 No symptoms. „ 29 .... ... 1/6 33 Ill. „ 27 .... .. 1/15 3) Ill. 1906. Nov. 3 .... .. 1/15 55 No symptoms. J Ml). 5 .... .. 1/3 55 No symptoms. „ 10 .... .. 1/10 55 No symptoms. „ 12 .... .. 1/6 55 No symptoms. „ 17 .... .. 1/10 33 Ill. „ 19 .... .. 1/4 33 No symptoms. „ 24 .... .. 1/10 55 Ill. ,3 26 .... .. 1/4 33 No symptoms. Dec. 1 .... ... 1/10 55 No symptoms. Feb. 2 .... .. 1/3 55 Ill. i, 8 .. 1/8 55 Ill. „ 9 .... .. 1/3 55 No symptoms. „ 15 .... .. 1/8 33 No symptoms. III.—Tests of Serum of Goat II. Date. December 29 ... J) 55 55 55 January 19, 1906 55 55 January 26 . 55 . 55 . February 2 . 55 . 55 . 55 . 55 . 55 . 55 . February 9 . 55 .. 55 .. 55 . 55 .. 55 .. Test animal. Amounts injected. Results. .Rabbit 1 1/20 c.c. serum -t-1 c.c. toxin. Alive. ,5 2 1/50 „ +1 Dead. „ 3 1/100 „ +1 Alive. ,3 4 Control, 1/5 c.c. toxin. Dead, 2 hours. ,3 5 „ 1/10 Diarrhoea and collapse. „ 1 1/50 c.c. serum +1 c.c. toxin. Alive. „ 2 1/100 „ +1 Dead. „ 3 Control, 1/10 c.c. toxin. 55 „ 1 1/50 c.c. serum + 1 c.c. toxin. Alive. „ 2 1/100 „ +1 Dead. 93 3 Control, 1/10 c.c. toxin. 55 „ 1 1/10 c.c. serum + 1 c.c. toxin. Alive. 9, 2 1/20 „ +1 55 33 3 1/50 „ +1 55 „ 4 1/50 „ +1/2 55 33 5 Control, 1/10 c.c. toxin. Dead, 2| hours. „ 6 1/20 „ 33 2 „ „ 7 „ 1/30 33 18 33 „ 1 1/50 c.c. serum + 1 c.c. toxin. Alive. 3, 2 1/50 „ +1 55 3, 3 1/100 „ +1 Dead. ,3 4 1/100 „ +1/2 Alive. ,, 5 Control, 1/10 c.c. toxin. Dead. ,3 6 „ ' 1/20 Diarrhoea and collapse. Three goats are in process of immunisation by this method of small and gentle dosage and have not up to the present succumbed. It will be observed that whilst in the case of Goat I the dosage was raised from