Molecular structure of human chromosomes / edited by Jorge J. Yunis.

Date:
1977
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Molecular structure of human chromosomes / edited by Jorge J. Yunis. Source: Wellcome Collection.

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    vi Contents 3 Human Gene Localization by RNA:DNA Hybridization in Situ Dale M. Steffensen I. Comments on Isolating and Labeling RNA 60 II. Methods of in Situ Hybridization 62 III. Gene and Genome Evolution in Primates 66 IV. Ribosome Genes 68 V. Clinical Applications of in Situ Hybridization 78 VI. Localizing Genes at Inteфhase 80 VII. Messenger and Transfer RNA 82 References 84 4 New Approaches to Human Gene Mapping by Somatic Cell Genetics Richard P. Creagan and Frank H. Ruddle 1. Introduction 90 II. Family Studies 91 III. Somatic Cell Hybridization 97 IV. The Human Gene Map 121 V. New Mapping Methods 121 References 129 5 Chromosomes and Chromatin Structure G. F. Bahr I. Introduction 144 II. Composition of Chromatin 144 III. Fibrous Nature of Eukaryotic Chromatin 149 IV. Arrangement of Chromatin Fibers in Chromosomes 156 V. Relation of Chromosome Structure to the Banding Pattern of Chromosomes 178 VI. Aberrations Reflecting the Fibrous Nature of Chromosomes 181 VII. Materials and Methods 193 References 194 6 Premature Chromosome Condensation and the Fine Structure of Chromosomes Potu N. Rao 1. Introduction 205 IL Structure of Prematurely Condensed Chromosomes (PCC) 209 III. Chromosomes of Differentiated Cells 221 IV. Prematurely Condensed Chromosomes for Study of Chromosome Aberrations 222 V. Conclusions 229 References 229
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