On the influence of muscular exercise, sweating, amd massage, on the metabolism / by J.C. Dunlop ... [and others].

Date:
[1897]
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Licence: Public Domain Mark

Credit: On the influence of muscular exercise, sweating, amd massage, on the metabolism / by J.C. Dunlop ... [and others]. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    [Reprinted from the Journal of Physiology. Vol. XXI/. JVos. 1 <5c 2, September 1, 1897.] ON THE INFLUENCE OF MUSCULAR EXERCISE, SWEATING, AND MASSAGE, ON THE METABO- LISM.1 By J. C. DUNLOP, M.D., F.R.C.P. (Ed.); D.NOEL PATON, M.D., F.R.C.P. (Ed.), B.Sc.; R. STOCKMAN, M.D., F.R.C.P. (Ed.), and IVISON MACCADAM, F.R.S. (Ed.). (From the Laboratory of the Royal College of Physicians, Edinburgh, and the Chemical Laboratory, Surgeon's Hall, Edinburgh.) Since Liebig in 1842 developed his famous theory of the source of muscular energy, the influence of muscular work on the metabolism has arrested the attention of many physiologists, and much has been recorded on the subject. From previous observations, we now know that while the principal source of energy is in the non-nitrogenous constituents of the body, the nitrogenous constituents are always decomposed to a greater or less extent if the work is at all excessive. The object of the present research is to attempt to elucidate the source of the proteid material decomposed after muscular work, and generally reinvestigate the subject. The excretion of uric acid and allied nitrogenous bodies and of phosphoric acid received special attention, for an indication of the source of the proteid decomposed may be found in the influence of muscular work on these excretions. Muscular tissue is rich in the native proteid, e.g. globulin, but is poor in nucleo proteids, and consequently, were it found that the increased excretion of nitrogen were accompanied by increased ex- cretion of uric acid and allied bodies, along with an increased excretion of phosphoric acid, substances derived from the decomposition of the nuclein element of nucleo proteids, it would indicate that not muscle but some other tissue supplied the proteid. It is an established fact that in hunger the proteid of one tissue can be called on to supply the wants of another2, and it is of interest to know whether such an 1 The expenses of this Besearch were paid out of grant from the British Medical Association. 2 Cp. Neumeiater'a Physiologischcn Chemie. i. p. 277; and also a paper by Paton, Dunlop and others on the metabolism of Salmon in fresh water to be published shortly in the Scottish Fishery Board Beports,