Uric acid : the chemistry, physiology and pathology of uric acid and the physiologically important purin bodies, with a discussion of the metabolism in gout / by Francis H. McCrudden.

  • McCrudden, Francis H.
Date:
1905
Catalogue details

Licence: Public Domain Mark

Credit: Uric acid : the chemistry, physiology and pathology of uric acid and the physiologically important purin bodies, with a discussion of the metabolism in gout / by Francis H. McCrudden. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

    320/338 (page 304)
    uric acid infarcts in 140 cases, and no infarcts in 160 cases, out of 304. According to Spiegelberg/ infarcts are found in more than half the children dying under two weeks of age. Flensburg ^ studied twenty cases and found infarcts in every case. In accord with the old view, the infarcts were looked upon as indicating low oxidation processes in the first few days of life whereby less urea and more uric acid are formed than normally.^ They are now generally considered simply the result of precipi- tation from urine which is highly concentrated in uric acid. Thus Martin and Ruge,* Flensburg,^ Schreiber,^ Reusing,^ Mares,^ and Sjoquist ^ found the excretion of uric acid very high in the first few days of life. Mares found that | per cent of the total nitrogen of young infants is excreted as uric acid. This fraction is only ^ per cent in adults. Reusing found the ratio of uric acid to urea from 1 : 1.5 to 1 : 6.5 during the first few days of life, an exceedingly high ratio. This author likewise called attention to the fact that the infarcts were more common in children naturally fed than in those fed artificially. The latter get much more fluid, and therefore the urine is not so likely to become saturated with uric acid. The quantity of urine excreted in twenty-four hours increases rapidly with age during the early days. The uric acid excretion is nearly stationary for a while. The uric acid excreted by infants is endogenous uric acid. There are no purins in milk food. As we should expect, the amount excreted does not varj' with the quantity of food, accord- ing to Reusing. Schreiber believes with Horbaczewski that the ' H. Spiegelberg. Ueber den Harnsaureeinfarct der Neugebornen. Arch, fiir exp. Path. u. Pharm., 41, 428 (1898). ^C. Flensburg. Studier ofver Urinsyreinfarkten, urinsedimentet och albuminurin hos nyfodela. Nord. med. Arkiv. (1894), No. 9 and No. 14. Centralblatt fiir innere Medizin, 15, 965 (1894). 5 Vierordt. Physiologie des Kindesalters in Gerhard's Handbuch der Kinderkrank- heiten, IV, 374. ^Martin und Ruge. Zeitschr. fiir Geburtshiilfe und Frauenkrankheiten, 1, 273 (1875). ^ E. Schreiber. Gicht. Ueber die Harnsaure unter physiologischen und pathologi- schen Bedingungen. Stuttgart (1899). ^ H. Reusing. Beitrage zur Physiologie des Neugebornen. Zeitschr. fiir Geburtshtilge und Gynakologie, 33, 1 (1895). ^ F. Mares. Sur I'origine de I'acide urique chez rhomme. Arch, slaves de biologie, III, 207 (1888), also Centralblatt fur die med. Wissenschaften. 26, 2 (1886). ' J. Sjoquist. N&,gra analyser ofvers quafrets fordelning pa urinsaurne urinsyra och ammoniak i urinen hos nyfodde barn. Nord. Med. Arkiv. (1894); Maly's Jahresb. uber die Fortschritte der Thierchemie, 23, 245 (1893).