Find thousands of books, manuscripts, visual materials and unpublished archives from our collections, many of them with free online access.

MGG stained smear of a C2 vertebral chordomal mass

  • William R. Geddie
  • Digital Images
  • Online

Available online

view MGG stained smear of a C2 vertebral chordomal mass


CC0 1.0 Universal
You can use this work for any purpose without restriction under copyright law.
Creative Commons Zero (CC0) terms and conditions
Credit: MGG stained smear of a C2 vertebral chordomal mass. William R. Geddie. CC0 1.0 Universal

Selected images from this work

About this work


Chordomas are cancers formed of cells which resemble those of the notochord (spine) of a developing foetus. Although they can present anywhere within the spine and skull, the majority grow in the sacral region of the spine, corresponding to the lower back. This image shows an MGG (May Grünwald Giemsa) stained smear obtained from a needle biopsy of a chordoma of the C2 vertebrae, located at the top of the neck just underneath the base of the skull. Chordomas are relatively benign in the sense that they grow slowly and do not metastasize (spread to other parts of the body). However, their relentless growth with compression of the spinal cord often causes considerable problems with the adjacent nerves, brain and spine. They can be recognized in fine needle biopsy samples by characteristic large cells with vacuoles (bubbles) in their cytoplasm called physaliferous cells which grow in lobules (lumps). In this image, the vacuoles can be clearly seen in the seen amongst the pale blue cytoplasm of the cells, the nucleus of which are stained purple, amongst a background of myxoid (mucous-like) material. The MGG stain is particularly good at highlighting the characteristic myxoid background, as in this image. Horizontal image width 675 micrometres


Permanent link