The properties of polymethylene bistrimethylammonium salts / by W.D.M. Paton and E.J. Zaimis.

  • Paton, William D. M.
Date:
[1949?]
Catalogue details

Licence: In copyright

Credit: The properties of polymethylene bistrimethylammonium salts / by W.D.M. Paton and E.J. Zaimis. Source: Wellcome Collection.

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    2 anticholinesterase action, which may account for some of the effects j mentioned. It is considerably more active against ‘true’ than ‘pseud cholinesterase. It has a very feeble muscarine-like action, and no detecta atropine-like action. In large doses, it paralyses autonomic ganglia. C5, although virtually devoid of curarizing action at the neuromuscu junction, is very active in paralysing transmission at the ganglionic synap A small dose (0-2 mg./kg.) injected intravenously into the cat anaestheti: with chloralose causes relaxation of the nictitating membrane (excited to c traction by preganglionic stimulation). A slightly larger dose causes a fall blood-pressure, which is abolished by a paralysing dose of nicotine. A furt increase in dose prevents the bradycardia due to peripheral stimulation of cut vagus. Tested by the technique of Feldberg & Lin (1948), C5 in srj amounts abolishes the peristaltic reflex of rabbit intestine. Doses of the d j however, sufficient to cause paralysis of ganglionic transmission, do not dimi l the release of acetylcholine by the preganglionic nerve terminals of the perft) superior cervical ganglion, and do not alter the effects of postganglionic stij lation. j Besides opposing the curarizing action of CIO, C5 antagonizes the pow 1 C10 and of acetylcholine to cause contraction of the frog’s rectus. C5 poss f- no anticholinesterase activity or muscarine-like action, nor any of the st lating properties possessed by nicotine. REFERENCES i Eeldberg, W. & Lin, C. Y. (1948). J. Physiol. 107, 37P. Organe, G., Paton, W. D. M. & Zaimis, E. J. (1949). Lancet, 256, 21. Paton, W. D. M. & Zaimis, E. J. (1948a). Nature, Lond., 161, 718. Paton, W. D. M. & Zaimis, E. J. (19486). Nature, Lond., 162, 810.