Volume 12

Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose.

Date:
1909-
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose. Source: Wellcome Collection.

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    IV. 7, aged 72, is a sailor in a whaler to Greenland; his hands and feet are much deformed but he is quite active for his age. IV. 8 died from tuberculosis at 46; he was badly affected in hands and feet. IV. 10, 12 and 14 are healthy and show no signs of muscular atrophy. IV. 15, aged 58, a cooper, with light blue irides and dark hair, is free from muscular atrophy; he has had pleurisy and pneumonia but is still working. IV. 16 died, aged 27, from phthisis; he was badly affected. IV. 17 and 18 were reported to be unaffected. IV. 19 is reported to be affected in his feet and to walk with difficulty. IV. 21 died aged 56, a fisherman; Dr Findlay was told, by his children and his siblings and by other relatives, that this man was very badly affected in hands and feet; he was said to walk on the sides of his feet and to have claw hands; otherwise he was healthy. IV. 23, 27 and 31 are unaffected. IV. 28 died in infancy. IV. 26, aged 76, is an intelligent woman with a great memory about past events; she has made a study of the family affection and was able to give valuable help; she has blue eyes and dark brown hair; she is a healthy woman, unrelated to her husband. IV. 29, aged 61, a labourer, with light blue eyes and light brown hair, is mentally keen; he alleged that he had no trouble with his feet, though walking was evidently very difficult; his hands were thin and long with wasting of the thenar and hypothenar eminences; his hand grips were good; his lower extremities showed general muscular wasting below the knee; he had marked pes cavus and some talipes equino-varus; his toes were clawed; the movements of his toes and ankles were very limited; his knee-jerks and plantar reflexes were absent; the affection was more advanced in the left foot than the right; no nystagmus was present. Of the sibship, IV. 32-37, several were abroad and believed to be healthy; IV. 36 died from phthisis. IV. 33 died from phthisis at the age of 63; he was Dr Findlay’s patient; there was much general wasting due to his pulmonary disease, but muscular atrophy of his feet, legs, hands and forearms was very marked before he became acutely ill; the wasting was most marked in his hands, especially in the thenar and hypothenar regions; his fingers were markedly clawed and his thumbs were quite unable to oppose his fingers; the tubercular condition seemed to hasten the advance of an otherwise slow progress of the atrophy. IV. 38, aged 72, a retired labourer, with blue irides and dark hair, was unaffected. IV. 39 is reported to be healthy and unaffected. IV. 41, aged 60, is said by her brothers to have affected feet; the onset of the disease was at about the age of 25; in other respects she is healthy. IV. 42-47 were not seen, but all were reported to be free from muscular atrophy; IV. 46 died from dropsy, IV. 48, a postman, aged 53, was unaffected. IV. 49, aged 45, has blue eyes and dark hair; his lower extremities are affected, hands and arms are normal; a barrel of oil fell on his right foot 14 years ago and dislocated his ankle inwards; his plantar arches are flat; muscular wasting has occurred in his legs and feet; movements are fairly good; slight pes varus was noted in the left foot; knee-jerks are active; sensation is good; this man has no nystagmus and no Rombergism. IV. 50 is healthy. IV. 51 died, aged 13, from phthisis. Members under IV. 52 are said to be unaffected. IV. 54, a stout, well-built woman, aged 53, has grey irides and light brown hair; she had no trouble with her hands and feet until about the age of 30, when she noticed a tendency “to go over” on the outside of her left ankle and had to walk very carefully; her left foot shows slight equino-varus, the arch is slightly raised and slight wasting of the muscles of the foot and ankle has occurred; her leg muscles are normal and her right foot is not affected; her left hand shows slight wasting of the thenar and hypo thenar eminences; both little fingers are extended at the metacarpo-phalangeal joints, flexed at the middle phalangeal joints; her right hand shows no wasting; knee-jerks, ankle-jerks and plantar reflexes are absent; sensation is normal. IV. 55, aged 51, has affected hands and feet; she first noticed the trouble at the age of 30, in upper and lower extremities at about the same time; she is a very active plucky little woman, insisting that she is not hampered by her disability and “can wring out clothes better than most people”; her hands are clawed and show severe wasting of the small muscles; the thenar and hypothenar eminences are flattened; her forearms appear to be rounded and firm and are probably not yet affected; her feet show a considerable amount of drop-foot and she has little power of movement in her toes or ankles but muscular wasting is not a conspicuous feature in her feet or legs; her toes are straight and there is no gross deformity in her feet; her knee-jerks and ankle-jerks are absent. IV. 57, aged 49, has dark blue irides and grey hair which was fair in youth; this woman is suffering from car cinoma of the uterus; she first noticed a weakness on the outer side of her left leg and ankle at the age of 14; the right side became affected some years later; she has never had pain in the affected areas; her right hand shows wasting of the thenar and hypothenar eminences and very slight wasting of the interossei; wasting in her left hand is much less marked; her fingers are straight and all movements are normal; her thumbs are able to adduct and abduct fairly well; her left foot hangs, rather limp, in the equino-varus position; she has pes cavus and the toes are all flexed; she cannot dorsiflex the foot nor abduct it; fine muscular tremors were seen in this foot; her right foot is only very slightly affected, wasting is not marked in it and movements are fairly good; knee-jerks, ankle-jerks and plantar reflexes are absent; her sensation to a blunt pointed instrument is normal, tested with wool it is deficient on the peroneal side of her left leg and foot. IV. 58, aged 45, has had a tubercular left hip joint since the age of 5 and at present has chronic discharging sinuses; her left foot only shows the atrophy to be expected as a result of the hip-joint disease and movements at the ankle and toes are normal; her right foot lies in the equinovarus position; the dorsum is high and the arch raised; the toes are slightly flexed and have 5-3