The influence of sodium benzoate on the nutrition and health of man.

  • United States. Department of Agriculture. Referee Board of Consulting Scientific Experts.
Date:
1909
Catalogue details

Licence: Public Domain Mark

Credit: The influence of sodium benzoate on the nutrition and health of man. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    H. voNi Fknyvesey. Uber tlcii KinfluHs experimentell erzeugter Krankheits-pro- cessoauf biocbemische SyiUbeHen. Maly's JahreHborichl fiir Thiorrhomic, 1906, XXXVI, 033. (()ri<,Miial in Hungarian.) The synthesis of hippiiric acid is considerably diminished in ral)liils poisoned witli lnuteriaj loxins. I'\ liALDi. Contiibuto alia .studio doU' ar-ido ippurico nell' organismo umano. 11 Poliflinico, Scz. mod., 1907, No. G. [AbHtract in Zentralblatt fiir die g(wammte I'hysiologie und Pathologio doe Stoffwechsels, 1907, 11, 748.] Author reports e.^porimcnls to show that part or tlic hippiiric -mUI ii\ay he, synthclized In the intestine. M.\(;\us-Levy. Uber das Auftreten einer Benzoesauro-Glycuionsiiure Verbinduiig iui llaminelharn nach Benzoesiiure Fiitterung. Biochemische Zeitschrift, 1907, VI, 502. licnzoylglycuronlc acid Is excreted after giving benzoic acid to dogs, rabbits/rams, and men. As much as 20 per cent of the introduced benzoic acid may appear in this form. .\lA(iNUS-LEVY. ijber die Neubildiuig von GlycocoU, etc. Biochemische Zeit- schrift, 1907, VI, 523. In the body more glycocoU can lie produced than exists preformed in the proUnn decomposed. There was a definite increase in protein decomposition after larger doses of benzoic acid in a starving ram. S. Amberg and A. Loevenhart. Further observations, etc. Journal of Biological Chemistry, 1908, IV, 149. Sodimn benzoale in concent rat ion of 1 per cent does not inliibit the lipolytic action of clear liver extract on ethylbutyrate. Lewinski. Uber die Grenzeii der Hippursiiurebildung beim Menschen. Archiv fiir experimentelle Pathologic und Pharmacologic, 1908, LVIII, 397. A man weighing 59 kilograms took 12 grams of benzoic acid as sodium benzoate in 12 hours on a mixed diet. He excreted no free benzole acid and the urine contained no reducing substance. The l)enzoic acid was all excreted in combination. .A man of 67 kilogram.s body weight took 20 grams of benzoic acid in 12 hours without ill effects. There was no free benzoic acid or reducing substance in the urine; but after an intake of 25 grams of l)enzoic acid without ill effects, 1.6 grams of free benzoic acid were excreted. When the same individual took in 8 hours 40 grams of benzoic acid in one-half hour doses, there was nausea and headache; 26 per cent of the introduced benzoic a<'id was excreted as free b(>nzoio acid. The urine reduced strongly and was dextro- rotatory. With a diet rich in proteins, particularly gelatine, 40 grams of benzoic acid produced no ill effects; 10 per cent of the introduced acid was excreted as free benzoic acid. The urine reduced slightly and showed slight dextro-rotation. Similarly .50 grams of benzoic acid showed no ill effects. Sixteen per cent reappeared as free benzoic acid and there was slight reduction, etc., in the urine. The author concludes that a person taking a diet rich in proteins can transform more benzoic acid to hippuric acid. The appearance of reducing substance in the urine is an expression of the impoverishment of the organism in glycocoU. In certain forms of nephritis there was a retarded elimination after ingestion of Ijcnzoic acid. In one individual 40 grams of benzoic acid and 25 grams both caused increase of nitrogen excretion. In a man of 71 kilograms on a diet poor in proteins, ?.0 grams of benzoic aci<i caused increase of nitrogen excretion and diminished m'ic acid output. Sec. Uber die Hippursamespaltung durch Bacterien, etc. Archiv fiir experi- mentelle Pathologic und Pharmacologic, 1908, LVIII, 440. Hippuric acid may readily be decomposed by bacterial action in the urine, especially when the reaction is alkaline. This may explain the conflicting results of investigators. H. W. Wiley, with the collaboration of W. D. Bigelow, F. €. Weber, and others. Influence of Food Preservatives and Artificial Colors on Digestion and Health. IV. Benzoic Acid and Benzoates. United States Department of Agriculture, Bureau of Chemistry. BuUetui No. 84, Part IV, 1043-1294, 1908. Benzoic acid and benzoate of sodium were administered in capsules in doses of 0.9 to 2.5 grams daily to healthy young men (18 in all) during successive periods of several days. The longest single period was 20 days. During one period of 10 days, doses of 1 to IJ grams were given. The authors state that marked symptoms of discomfort and malaise were produced in the majority of cases without reference to the fonn in which the preservative was administered; most common symptoms were nausea and headache. The nausea resulted in vomiting in three cases. Seven