The influence of sodium benzoate on the nutrition and health of man.

  • United States. Department of Agriculture. Referee Board of Consulting Scientific Experts.
Date:
1909
Catalogue details

Licence: Public Domain Mark

Credit: The influence of sodium benzoate on the nutrition and health of man. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    K. SiMUo. i'bor NaehweiM und X'oikomnuMi tics (Jlykokolln. Zoi(fichrift fiir pliysio- logisc-ho ('hcmio, 1SS)9, XXVIIl, 171. Author obtainod no syntliosis of liippuric acid from IxMizoic acid and j;lyc(x'oll with tissue press juice, and tliinks tliat survlvinf; colls arc necessary. II. Lefkmann. Diijestivc fonnonts, with especial reference to the el'lect of food ])reservalive.s. Journal of the Franklin Institute, 1899, CXLVII, 97. Benzoic iwid and sodium l)onzoate arc practically witliout influence on the diRestivc jjower of the enzymes studied (diivstiiscs, carase, pancreatic extracts), excepting higher concentrations. Tlie author adds tliat as the preser\-ative influence of sodium henzoate is iindoubted and its dis- agreeable taste in any food article will prevent its liberal use it seems well adapted for general use. sM.KdwsKi. Uber die antiseptische W'irkung von Salicylaldehyd und Benzo^•.^au- reanhydrid. Virchow's Archiv fiir patholoj^ische Anatomio, 1899, CLVII, 41G. In concentration of 0.!S per cent benzoic acid anhydrid kept chopped meat mixture sterile more than 5 months: similarly 0.25 per cent. With 0.1 per cent a few colonies were grown after this lime, while with 0.025 per cent the mixture showed cultures after 5 days. -V.sHHURST. Certain effects of benzoic acid upon the urine. Philadelphia Medical Journal, Feb. 24, 1900. In dogs 1 to 2 grams of sodium l)enzoate administered subcutancously for several days produced slight and inconstant diuretic elTcct. A dog received 1 gram of sodium beuzoate daily during 2 months. No ill effects are mentioned. The author took 0 grams of sodium henzoate daily during 6 days. The quantity of urine was somewhat increased, the specific gravity slightly altered, the acidity slightly diminished. Ui-UMENTHAL. Zur Methode der Ilippiirsiiiirebestimmung. Zeitschrift fiir klin- ische Medizin, 1900, XL, 339. M. Lewandowsky. Versuche iiber den Einfiuss der Benzoesaure auf die llarn- saurebildung. Zeitschrift fiir klinische Medizin, 1900, XL, 202. A patient received 35 grams of sodium henzoate in 5 days; 15.5 grams were excreted as hippuric acid. There was no decrease of uric acid. This indicates that the formation of hippuric and uric acids are independent of each other. Three patients were fed with sodium licnzoate for 2 to 7 days, and doses between 5 nnd 9 grams per day. In two cases a peculiar sleep-producing action gf benzoic acid was noted. Abelous and Ribaut. Sur I'existence d'un ferment soluble operant la synthase de I'acide hippurique aux depens du glycocolle et de I'acide benzoique. Compt&s Rendus de la Societe de Biologie, June 9, 1900. The hippuric acid synthesis by kidney tissue is due to an enzyme action. Weintraud. ijber den Abbau des Nucleins im Stoffwechsel. ('entralblatt fiir innere Medizin, 1900, XXI, 464. An occasional increase of hippuric acid excretion after thjanus feeding is due to increased intes- tinal putrefaction which furnishes the benzoic acid radical. Parker and Lusk. On the maximum production of hippuric acid in rabbits. American Journal of Physiology, 1900, III, 472. In fasting rabbits toxic SJ^nptoms and death resulted when 1 to 0.4 gram of benzoic acid as litliiuin salt was given for ti days. In fasting rabbits frequently fed with lithium benzoate the amount of glycocoU eliminated as hippuric acid compared with the total nitrogen output indicates that in metabolism the protein molecule may yield glycocoU to the extent of at least 3 to 4 per ami. v.. (uRTis. Benzoic acid and Benzoates. Reference Handbook of the Medical Sciences, 1900, Vol. I. In discussing dosage the author states that a serious derangement is scarcely possible by any likely doses of benzoic acid, intentional or accidental. In urinary disorders benzoic acid may l)e given several times daily in doses from 0.(.5 to 2 grams. Sodium benzoate has been given internally in doses amounting to 5 to 20 grams a day without serious derangement, and for pronounced thera- peutic effect in rheumatism the fullest limit may be necessarj. Physiologically sodium benzoate is about as harmless as a salt can be. U. CoHN. Uber den GlykokollvoiTat des tierischen Organismus. Festschrift fiir M. Jaffe, Braunschweig, 1900 or 1901, p. 319. Feeding with proteins, and protein decomposition products which yield glycocoU. counteracts the toxic effect of Ix-nzoic acid in rabbits.