The influence of sodium benzoate on the nutrition and health of man.

  • United States. Department of Agriculture. Referee Board of Consulting Scientific Experts.
Date:
1909
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Licence: Public Domain Mark

Credit: The influence of sodium benzoate on the nutrition and health of man. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

    818/834 page 774
    .Sf.vator. Uber die Wirkung dt*r IJenzoesiiuie bei der rheumatincheji Pdlyarthritis. Zeitschrift fur klinische Medizin, 1879, I, 243. The author administered sodium benzoate in doses of 4 to 6 grams per day without llie slightest ill effect, then increased it to 11 to 12 grams. In acute rheimiatism as much as 70 grams of sodium benzoate were given during the course of the disease, u.sually within 11 days, without any s>nnj)tonis of irritation. Soon after administration the urine acquired strong reducing properties. Fritsche. [In a discussion of a paper on inhalations of sodium benzoate in tubercu- losis of the lungs.] Berliner klinische Wochenschrift, 1879, XVI, 7G2. Untoward eiTects reported in the treatment of a tubercular patient with inhalations of sodium benzoate. M. ScHULLER. tjber therapeutische Versuche bei mit liiberculosen, scrophuloseu, Beptischen Massen inficierten Tieren. Archiv fiir experimentelle Pathologic und Pharmacologie, 1879, XI, 84. The author states that it is possible for an adult to take 20 to .30 grams of sodium l)enzoate per day internally without injurious effect. F. Kroczak. Vorlaufige Mitteilung iiber Natronbenzoicum Inhalationen am Krank- enbette. Wiener medizinische Presse, 1879, XX, 1178. Sai.omox. L'ber den Ort der Hippursaurebildung beim Pfianzenfres.ser. Zeit- schrift fur physiologische Chemie, 1879, III, 365. In rabbits benzoic acid or benzoic acid plus glycocoU given per os leads to the formation of lii])- puric acid. In herbivora the kidneys are not the onlj- organs where this sjnithesis takes place, but in dogs the idea of Bunge and Schmiedeberg that the kidney is (he only place of the sjTithasis is still valid. (Salkowski.) Vox Schroder. LToer die Bildung der Ilippursiiure im Organismus des Schafcs. Zeitschrift fiir physiologische (.'hemic, 1879, III. 323. Author took 0.5 gram of benzoic acid in KOII, with a diet of potatoes and butter. The strongly alkaline, turbid urine contained no trace of benzoic acid. In rams fed on potatoes and beans 5 to 6 grams of benzoic acid given per os as potas.sium salt reappeared in urine mostly as hippuric acid (77 to 90 per cent) with relatively small amounts of free benzoic acid (4 to 23 per cent). Only small amounts of the introduced benzoate were unac^counted for. (is. \\'eiske.) R. Demme. Sechszehnter mediz. Bericht iiber die Thiitigkeit des Jennerschen Kinderhospitals in Bern im Laufe des Jahres 1878. Schmidt's Jahrbiicher fur die ge.^ammte Medizin, 1879, CI.XXXIII, 218. Diphtheria is treated vrith 5 to 20 grams of sodium benzoate per day, besides local treatment with it and subcutaneous injections of a 50 per cent solution in retro and submaxillary region and in the tonsils. There was no drop of temperature: the heart action was improved and urine secretion increased. Stadelmaxx. Uber die Umwandlung der ('hiiia.saure in liippursaure im Organ- ismus der Saugetiere. Archiv fiir experimentelle Pathologic und Pharma- cologie, 1879, X, 317. The sodium salt of quinie acid produces an increase in hippuric acid in lierbivorous animals (rabbits), but none in carnivorous animals (doirs). The output does not account for the amount of quinie acid introduced, and appears after a relatively long time. RoKiTANSKY. Zur Behandluug der Phthisc mittelst Inhalationen von Natrium benzoicum. Wiener medizinische Presse, 1S79, XX, 1330. Inhalations of sodium benzoate are reported to be of great value in phthisis. .V patient of 50 kilograms must use at least 50 grams in 5 per cent solution per day, the dose lieing determined by the body weight. Patient must inhale 1 gram per kilograin. It is a-ssumed to reach the lung in sufTicient concentration to act bactericidally. W. KocHS. iiber eine Methode zur Bestimmung der Topugraphie des ( hemismua im tierischen Korjjer. Pfliiger's Archiv fiir die gesamrato Phy.'=iologie, 1879, XX, 64. Confirmation of the Bunge-Schmiedeberg experiments on hippuric a<'id-formation after trans- fusion of dog kidney wnth blood plus glycocoll plus benzoic acid. The s.\iithesis also takes place in the presence of comminuted kidney of dog. ox, and calf. Experiments with liver (dog, calf) were negative.
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