On urobilin / by Archibald E. Garrod and F. Gowland Hopkins.

  • Garrod, Archibald E. (Archibald Edward), Sir, 1857-1936.
Date:
[1896]
Catalogue details

Licence: Public Domain Mark

Credit: On urobilin / by Archibald E. Garrod and F. Gowland Hopkins. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    By ARCHIBALD E. GARROD, M.A., M.D., F.R.C.P., and F. GOWLAND HOPKINS, M.B., B.Sc, F.I.C. (Plate I.) a Section I. Historical Sketch. II. The Separation of Urobilin from Urine, in. The Properties of Urobilin. rV. Are there Two kinds of Uruiary Urobilin? V. Faecal Urobilin. VI. The Urobilin of Bile. Conclusions. I. Historical Sketch. The earliest practical outcome of the application of the spectroscope to the study of the colouring matters of urine was the discovery by Jaff6\ in 1868, of the substance which yields the well-known absorption band between the h and F lines of the solar spectrum. Jaffe detected the presence of this pigment both in normal and morbid urines, and showed that it exists in them in part ready-formed, and in part as a precursor, or compound, of negative spectroscopic properties, which readily becomes converted into the baud yielding pigment on standing, or on the addition of an acid. To this substance Jaff^ assigned the name of urobilin, believing it to be derived from the pigment of bile, and subsequent investigations have converted this belief into a practical certainty. He quickly recognised the fact that urobilin is only one of several colouring matters of urine, and that it is not that to which its yellow colour is mainly due. The ninth volume (that for 1871) of the CentralhlaU fur die medicmische Wissenschaften, the periodical in which Jaff6 first announced his discovery, contains three short communications which must be ranked among the most important contributions yet made to our knowledge of this, the hitherto most extensively studied of the urinary pigments. . Centralblattf. die med. Wissenschaften, vi. p. 243. 1868. and VirMs ArcMv, XLvn. p. 405, 1869.