A study of doses : essay LVII / by William Sharp.

Date:
1890
Catalogue details

Licence: Public Domain Mark

Credit: A study of doses : essay LVII / by William Sharp. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

    10/48 (page 10)
    “Dec. 24, 1889. I cannot remember ever having had any eruption similar to that which followed my taking the Opium. It was quite a new thing to me. The only eruptions on the body that I can remember, have occurred twice or three times after over-heating myself with walking or other similar exertion. They lasted only a day or so, and were not accompanied by any itching.” Dr. Applebe.—“Oct. 2, 1889. I have much pleasure in sending you the results of a few experiments made on myself with Opium. “ Tincture of Opium B. P. Experiments made while in recumbent posture. Age 37; healthy, vigorous; normal pulse 64. Dose taken one drop. Time . 5 15 1 1 i 20 30 40j60 120 240 minutes. Pulse . 67 68 66 65,62 64 1 1 64 64 beats. Ttoo actions Dose taken five minims. Time • 5 15 20 30 40 60 ! 120 minutes. Pulse . 66 67 70 72 68 64 64 beats. One action of larger doses Caused slightly colicky pains in about fifteen minutes, which soon passed off. No drowsiness.” Dr. Applebe was requested to repeat on himself the expei'iment which had succeeded so well on the young milliner, as reported by him in the last Essay (LVI, page 11). “Nov. 17, 1889. 1 should begin by stating that I am most regular every morning after breakfast; the effect one dose of the medicine (two minims of Tinct. Op. B. P. in twelve ounces of water, a teaspoonful taken an hour before breakfast), had on me was that I had to go pretty quickly. I counted my pulse, it was about three beats quicker than normal. I think, however, this was attributable to the hurrying away so quickl}'^.” He was then asked to continue the same dose for eight or ten days. “Dec. 8, 1889. I have been giving the Opium a fair trial. I found for five days it had the effect I told you in my last letter, viz. having to hurry off rather quickly. No appreciable effect on tem- perature or respiration; pulse slightly quickened. On the sixth day, strange to say, I was constipated (a most